Methimazole-induced Acute Kidney Injury during the Initial Treatment for Graves’ Disease: a Rare Case Report and Literature Review
Abstract
As a commonly used oral drug for the treatment of hyperthyroidism, methimazole has common adverse reactions such as a granulocytopenia, thrombocytopenia, arthralgia, skin allergy, etc. The reports of kidney injury caused by methimazole are rare, and the clinical understanding is insufficient, so it is easy to misdiagnosis. This paper reports a middle-aged male patient who was diagnosed with hyperthyroidism in our hospital and developed acute kidney disease after treatment with methimazole. Creatinine and kidney injury-related protein levels decreased after treatment with methimazole. After the primary disease was excluded, acute kidney injury caused by methimazole was highly suspected. The aim of this paper is to improve the safety of methimazole and reduce the rate of missed diagnosis and misdiagnosis.
References
Li Y, Teng D, Ba J, et al., 2020, Efficacy and Safety of Long-Term Universal Salt Iodization on Thyroid Disorders: Epidemiological Evidence From 31 Provinces of Mainland China. Thyroid, 30(4): 568–579.
Chinese Society of Endocrinology, Chinese Medical Association, Chinese Society of Endocrinology and Metabolism, et al., 2022, Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis. International Journal of Endocrinology and Metabolism, 42(5): 401–450. DOI: 10.3760/cma.j.cn311282-20220624-00404-1
National Guideline Centre (UK), 2019, Management of Thyrotoxicosis: Anti-Thyroid Drugs. Thyroid Disease: Assessment and Management. National Institute for Health and Care Excellence (NICE), UK.
Kidney Disease Improving Global Outcomes, 2012, Clinical Practice Guideline for Acute Kidney Injury. Kidney Int Suppl, 2: 1–138.
Chawla L, Kimmel P, 2012, Acute Kidney Injury and Chronic Kidney Disease: An Integrated Clinical Syndrome. Kidney Int, 82(5): 516–524.
Hoste EA, Bagshaw SM, Bellomo R, et al., 2015, Epidemiology of Acute Kidney Injury in Critically Ill Patients: The Multinational AKI-EPI Study. Intensive Care Med, 41(8): 1411–1423.
Lewington A, Cerda J, Mehta R, 2013, Raising Awareness of Acute Kidney Injury: A Global Perspective of a Silent Killer. Kidney Int, 84(3): 457–467.
Leither M, Murphy DP, Bicknese L, et al., 2019, The Impact of Outpatient Acute Kidney Injury on Mortality and Chronic Kidney Disease: A Retrospective Cohort Study. Nephrology Dialysis Transplantation, 34(3): 493–501.
Murphy D, Reule S, Vock D, 2021, Acute Kidney Injury in the Outpatient Setting: Developing and Validating a Risk Prediction Model. Kidney Medicine Journal, 4(1): 100376.
Turgut F, Awad A, Abdel-Rahman E, 2023, Acute Kidney Injury: Medical Causes and Pathogenesis. J Clin Med, 12: 375. https://doi.org/10.3390/jcm12010375
Mehta RL, Pascual MT, Soroko S, et al., 2004, Spectrum of Acute Renal Failure in the Intensive Care Unit: The PICARD Experience. Kidney Int, 66: 1613–1621.
Liu C, Yan S, Wang Y, et al., 2021, Drug-Induced Hospital-Acquired Acute Kidney Injury in China: A Multicenter Cross-Sectional Survey. Kidney Dis (Basel), 7(2): 143–155.
Tan S, Chen L, Jin L, 2021, The Efficiency and Safety of Methimazole and Propylthiouracil in Hyperthyroidism: A Meta-Analysis of Randomized Controlled Trials. Medicine, 100(30): e26707.
Burch HB, Cooper DS, 2015, Management of Graves Disease: A Review. JAMA, 314(23): 2544–2554. DOI: 10.1001/jama.2015.16535
Shell A, Sullivan J, 2020, Acute Kidney Injury Following Methimazole Initiation: A Case Report. J Pharm Pract, 33(1): 99–101. DOI: 10.1177/0897190018789277.
Reynolds LR, Bhathena D, 1979, Nephrotic Syndrome Associated With Methimazole Therapy. Arch Intern Med, 139(2): 236–237.
Gameiro J, Marques F, Lopes J, 2020, Long-Term Consequences of Acute Kidney Injury: A Narrative Review. Clin Kidney J, 14(3): 789–804. DOI: 10.1093/ckj/sfaa177.
Bagshaw S, 2007, Epidemiology of Renal Recovery After Acute Renal Failure. Curr Opin Intern Med, 6: 31–37.
Yang L, 2019, How Acute Kidney Injury Contributes to Renal Fibrosis. Adv Exp Med Biol, 1165: 117–142.
Liu KD, Yang J, Tan TC, et al., 2019, Risk Factors for Recurrent Acute Kidney Injury in a Large Population-Based Cohort. Am J Kidney Dis, 73: 163–173.
Wynn TA, 2007, Common and Unique Mechanisms Regulate Fibrosis in Various Fibroproliferative Diseases. J Clin Invest, 117: 524–529.
Heung M, Steffick DE, Zivin K, et al., 2016, Acute Kidney Injury Recovery Pattern and Subsequent Risk of CKD: An Analysis of Veterans Health Administration Data. Am J Kidney Dis, 67: 742–752.
Chawla LS, Eggers PW, Star RA, et al., 2014, Acute Kidney Injury and Chronic Kidney Disease as Interconnected Syndromes. N Engl J Med, 371(1): 58–66.
Rodríguez-Romo R, Berman N, Gómez A, et al., 2015, Epigenetic Regulation in the Acute Kidney Injury to Chronic Kidney Disease Transition. Nephrology, 20: 736–743.
Rajesh R, Joseph R, Finny P, 2021, Carbimazole Induced Nephrotoxicity. Indian J Endocrinol Metab, 25(6): 571–573. DOI: 10.4103/ijem.ijem_339_21.
Bellomo R, See EJ, 2021, Novel Renal Biomarkers of Acute Kidney Injury and Their Implications. Intern Med J, 51: 316–318.
