Journal of Clinical and Nursing Research

Early Identification and Nursing Intervention Experience of a Case of Necrotizing Fasciitis

Xiaohong Rong, Xinyu Li, Luyu Wang — Fri, 17 Oct 2025 10:25:49 +0800

Objective: To explore the key points of early identification and comprehensive nursing intervention strategy for necrotizing fasciitis patients, to improve the efficiency of clinical diagnosis and treatment and the quality of prognosis. Methods: The clinical data of a 70-year-old female patient with right-hand trauma complicated by infection progressing to necrotizing fasciitis were reviewed and analyzed. Laboratory, imaging, and surgical findings were integrated to summarize the early identification features and key nursing considerations. Results: The patient retained the affected limb, albeit with some functional limitations, following early identification, timely surgical debridement, broad-spectrum anti-infective therapy, and comprehensive nursing care. Conclusion: The early clinical manifestations of necrotizing fasciitis are often subtle, and the disease progresses rapidly. This necessitates heightened vigilance among medical staff in all healthcare settings. Implementing multidisciplinary collaboration and systematic nursing interventions can improve patient prognosis while reducing amputation rates and mortality.

Research Progress on the Mechanisms of the Effects of Laparoscopic Sleeve Gastrectomy on Free Fatty Acids and Tumor Necrosis Factor in Obese Patients

Fri, 17 Oct 2025 13:09:26 +0800

Laparoscopic sleeve gastrectomy (LSG), as an effective treatment for morbid obesity and its metabolic complications, exerts its therapeutic effects by significantly reducing body weight and improving metabolic disorders. Its core mechanisms involve multi-level regulation of free fatty acid (FFA) metabolism and chronic low-grade inflammatory states (represented by tumor necrosis factor-alpha, TNF-α). This paper systematically reviews the direct impact of LSG on FFA dynamics (including lipolysis, tissue uptake, and oxidation), as well as the molecular pathways through which it indirectly regulates TNF-α by reducing adipose tissue inflammation, improving intestinal barrier function, and modulating epigenetic modifications (such as SCD gene methylation). Postoperatively, FFA and TNF-α form a bidirectional promoting feedback loop. LSG effectively breaks this vicious cycle of mutual promotion between the two under obese conditions by reducing FFA levels and inhibiting TNF-α expression. Lower FFA levels alleviate inflammatory signal activation, while reduced TNF-α inhibits lipolysis, collectively promoting the restoration of insulin sensitivity. A thorough understanding of these mechanisms provides a theoretical basis for optimizing surgical strategies and developing targeted therapies.

Dynamic Monitoring of Serum Cytokines and BISAP Scores in Acute Pancreatitis: Assessment of Severity and Prognosis

Xuhui Cui — Tue, 14 Oct 2025 17:05:31 +0800

Objective: To investigate the value of dynamic monitoring of serum interleukin (IL)-33 and tumor necrosis factor (TNF)-α levels in the early diagnosis, severity assessment and prognosis of acute pancreatitis (AP) combined with abdominal CT radiomics and intestinal microbiota data. Methods: A total of 170 AP patients were admitted immediately after the onset of the disease and divided into MAP group (85 cases) and SAP group (85 cases). The levels of serum IL-33, TNF-α, IL-6, and HMGB1, as well as the expression of miRNA-155 in extracellular vesicles (EVs), were dynamically monitored at multiple time points (0 h, 6 h, 12 h, 24 h, 3 d, 5 d, 7 d, 14 d) after admission. Abdominal CT radiomics analyzed the texture characteristics of pancreatic necrosis, and stool samples collected at admission were metagenomic sequencing of the gut microbiome. The Acute Pancreatitis Severity Bedside Index (BISAP) score is calculated within 48 hours of admission. Multivariate regression analysis assessed the independent effects of various factors on the prognosis of mortality groups. Results: Serum IL-33 and TNF-α levels in SAP patients were significantly higher than those in MAP patients (p < 0.05) at all time points, peaked on day 3, and decreased with treatment. The levels of these cytokines in patients with SIRS were also higher than in patients without SIRS (p < 0.05). The serum IL-33, TNF-α levels and BISAP scores in the mortality group were higher than those in the survival group (p < 0.05). Multivariate regression analysis showed that serum IL-33 (OR = 3.21, 95% CI: 1.12–9.23, p = 0.03), TNF-α (OR = 4.05, 95% CI: 1.37–11.96, p = 0.01), and BISAP score (OR = 5.67, 95% CI: 1.83–17.54, p < 0.01) were independent prognostic risk factors. Spearman correlation analysis showed that serum IL-33 and TNF-α levels were positively correlated with BISAP scores(r = 0.68, p < 0.01; r = 0.73, p < 0.01). Conclusion: Dynamic monitoring of serum IL-33 and TNF-α levels combined with BISAP score has important clinical value for early diagnosis, severity assessment, treatment guidance and prognosis evaluation of AP, and provides a basis for accurate diagnosis and treatment.

Reclassification of Cytokine-Based Immune- Mediated Inflammatory Diseases: Mechanisms and Therapeutic Advances of IL-1-Driven Inflammatory Diseases

Xin Dai, Dan Li, Yi Li, Boran Cao, Dongzhe Huang, Qi Yuan, Bin Li — Fri, 17 Oct 2025 11:20:04 +0800

Immune-mediated inflammatory diseases (IMIDs) represent a heterogeneous group of disorders driven by immune dysregulation, involving multiple organ systems and characterized by substantial clinical diversity. Traditional classification based on affected organs fails to capture shared pathogenic mechanisms and impedes the development of unified therapeutic strategies. In recent years, reclassification of IMIDs according to the dominance of key cytokine hubs has emerged as a focus of research. Interleukin-1 (IL-1), crucial in triggering and maintaining innate immune reactions, is key to the onset and continuation of inflammation. Aberrant activation of the IL-1 axis serves as a pathogenic driver in several prototypical auto-inflammatory diseases (AIDs) and plays a role in the development of inflammatory diseases like gout, hidradenitis suppurativa, recurrent pericarditis, and chronic recurrent multifocal osteomyelitis (CRMO), demonstrating a high degree of mechanistic convergence. Therapeutic strategies targeting IL-1 have shown favorable efficacy and safety in multiple clinical studies, with several agents approved for corresponding indications. As molecular mechanisms are further elucidated and biologic therapies continue to evolve, the IL-1 axis is increasingly recognized as a common inflammatory nexus within IMIDs. The reclassification framework centered on IL-1 provides a conceptual basis for the implementation of shared-treatment strategies across distinct diseases and establishes a theoretical and practical foundation for precision-targeted interventions.

Practice and Exploration of Target Management Model for Clinical Pharmacists in Primary Hospitals

Xia Zhan, Ting Zhou , Hongrong Bao — Wed, 22 Oct 2025 11:27:20 +0800

Objective To explore the target management model for clinical pharmacists in primary hospitals facing current shortages of clinical pharmacists, in order to improve the work efficiency and service quality of clinical pharmacy, and promote the high-quality development of clinical pharmacy in primary hospitals. Methods Developing a target management model, adopting a wide coverage work model of "1+1+N" (that is, 1 clinical pharmacist, 1 resident clinical department and N contracted clinical departments). According to the SMART principle, various work assessment indicators were quantified. This involved setting clear work goals, diversifying work methods, personalizing work methods, standardizing workflows, and using numerical assessment indicators. Regular supervision, inspection, feedback, and improvement mechanisms were implemented. Results The implementation of the target management model has made the work effectiveness of clinical pharmacists visualized. There were more than 200 annual consultations and multidisciplinary team (MDT) cases, with an opinion adoption rate of 90.2% and a patient improvement rate of 80.6%. More than 1500 rational drug use interventions were conducted, with a suggestion adoption rate of 83.5%. In terms of pharmaceutical indicators control. The intensity of antibacterial drug use in 2024 (without CMI adjustment) was 30.07 DDDs, significantly lower than the 2023 value of 33.54 DDDs, and also significantly lower than the provincial average (32.87 DDDs) and the average for hospitals of the same level (32.49 DDDs). The daily usage of intravenous infusion per bed for hospitalized patients was 2.09, a decrease from 2.15 in 2023, significantly lower than the provincial average of 2.71 and the average of 2.56 in hospitals of the same level. The amount of the second batch of national key monitoring drugs accounts for the value was 6.48%, significantly lower than the provincial average of 8.27% and the same level hospital average of 8.82%. In terms of chronic disease pharmaceutical management, taking the pharmaceutical management of patients with chronic heart failure as an example, the usage rates of RA inhibitors and β-blockers for heart failure in the management group were 87.88% and 80.81%, respectively, significantly higher than those in the control group (62.22% and 65.56%). Heart rate in the management group (69.54 ± 10.68 times·min^-1) was significantly lower than in the control group (80.04 ± 17.68 times·min^-1) (P<0.001). The low-density lipoprotein (1.69 ± 0.57 mmol·L^-1) was significantly lower than the control group (1.95 ± 0.77 mmol·L^-1) (P<0.001), and the 1-year readmission rate was 47.47%, significantly lower than the control group 56.67%. The Minnesota Quality of Life Score was (44.20 ± 10.78), significantly lower than the control group (55.89 ± 11.48) (P<0.001), indicating a significant improvement in the patient's quality of life. Conclusions The targeted management model for clinical pharmacists can effectively enhance communication and collaboration between clinical pharmacists and clinicians, improve the work efficiency and service quality of clinical pharmacists in primary hospitals, promote the work of clinical pharmacy towards standardization and scientificization, boost the high-quality development of pharmacy in primary hospitals, and also provide new ideas and methods for the management of clinical pharmacists in other primary hospitals.

Exercise-Induced Syncope During Treadmill Testing in a Sedentary Woman: A Case Report

Yu Zhang, Jian Huang — Wed, 22 Oct 2025 00:00:00 +0800

Vasovagal syncope (VVS), which is triggered by physical exertion, is typically observed in athletes or patients with structural heart disease. There have been few reported cases among sedentary individuals. This case report details the experience of a 42-year-old sedentary woman who fainted during a treadmill stress test. Despite the absence of abnormalities in baseline cardiac and neurological evaluations, the patient exhibited sinus arrest (lasting 5–12 seconds) with significant ST-segment depression during haemodynamic collapse. Comprehensive assessments, incorporating coronary angiography, echocardiography, cranial computed tomography (CT) and biochemical testing, excluded the presence of structural or ischemic heart disease, arrhythmogenic syndromes and cerebrovascular disorders. A Calgary Syncope Symptom Score of 3 confirmed the diagnosis of VVS, a diagnosis that was further substantiated by the patient's symptoms resolving spontaneously when she was positioned supine. This case demonstrates that exercise-induced syncope can occur in individuals who are physically unfit and have no cardiac abnormalities. Transient ST-segment changes in such cases reflect autonomic nervous system dysfunction rather than myocardial ischaemia. It is incumbent upon clinicians to consider a neurocardiogenic mechanism in sedentary patients presenting with exertional syncope despite a negative standard cardiac evaluation.

A Seven-Year Surveillance of Epidemiological Trends of Serratia marcescens with Different Infection Types in a Tertiary Hospital in China

Qingtang Zhu, Bo Liu, Jie Wu, Caiyun Chen — Thu, 16 Oct 2025 12:07:09 +0800

Objective: To explore the trend of detection and antimicrobial resistance of Serratia marcescens with different infection types for 7 consecutive years, to provide a reference for future studies for the control of S. marcescens infections and a rational selection of antibiotics. Methods: S. marcescens isolates were collected from 2014 to 2020, and the trend of detection and antimicrobial resistance were analyzed according to different types of infection. Results: For 7 consecutive years, the data showed that patients with S. marcescens infections were mainly from the intensive care unit (ICU) (384 isolates, 40.98%), and the isolates recovered were mainly from sputum samples (743 isolates, 79.30%). The number of isolated strains increased every year, and the average rate of detection ranged from 0.60% to 0.80%. The detection rate of S. marcescens with hospital-acquired infections (HAI) showed a downward trend and that of S. marcescens with colonization showed an upward trend. The detection rate of multidrug-resistant S. marcescens fluctuated between 8.33%–16.89%. The resistance rate of S. marcescens to piperacillin was 17.0%–29.06% and the resistance rate to piperacillin tazobactam was 2.95%–13.13%. For cephalosporin antibiotics, the resistance rates of S. marcescens to cefuroxime and cefazolin were > 99% and the resistance rates to ceftazidime and cefepime were < 13%. The resistance rate of S. marcescens to aminoglycoside antibiotics, especially amikacin, was the lowest. The resistance rate of S. marcescens with community-acquired infections (CAI) to carbapenems was higher than that with HAI and colonization. Conclusion: The different infection types of S. marcescens have different detection and epidemic trends. In addition, resistance to carbapenems is different across the strains.

Study on the Impact of Developmental Care on the Growth, Development and Sleep Quality of Premature Infants

Jie An, Yangui Liu — Thu, 16 Oct 2025 11:33:19 +0800

Objective: To explore the positive role of developmental care measures in promoting the growth and development of premature infants, and analyze their specific effects on improving the sleep duration and quality of premature infants. Methods: A total of 80 premature infants who met the inclusion criteria were selected by convenient sampling method and divided into an experimental group and a control group, with 40 cases in each group. The experimental group received comprehensive nursing intervention of developmental care during the nursing process; the control group adopted the traditional conventional nursing model. Results: There was no statistically significant difference in various physical indicators between the two groups of premature infants before nursing intervention. After nursing intervention, the scores of intellectual development level, psychomotor development index and various physical indicators of premature infants in the experimental group were significantly higher than those in the control group, and the difference was statistically significant. Conclusion: The implementation of developmental care for premature infants can significantly improve their various developmental indicators, which can not only effectively promote the rapid development of premature infants’ mental and physical growth, but also improve their sleep quality.

Research Progress on Hydrogen-Rich Water in Improving Ocular Surface Diseases and Oxidative Stress

Nanxing Ma — Thu, 16 Oct 2025 13:09:53 +0800

The occurrence and development of ocular surface diseases are closely related to oxidative stress. Excessive accumulation of reactive oxygen species (ROS) can lead to ocular surface cell damage and inflammatory responses. As a new type of antioxidant, hydrogen-rich water (HRW) has shown intervention potential in ocular surface diseases such as dry eye and conjunctivitis by selectively scavenging toxic ROS, inhibiting inflammatory pathways, and protecting ocular surface cells. Combining basic mechanisms and clinical evidence, this article explores the application value of hydrogen-rich water in ocular surface diseases, providing new ideas for the prevention and treatment of oxidative stress-related eye diseases.

Research Progress on the Mechanism of Helicobacter pylori Infection in Extra-gastrointestinal Diseases in Children

Liuchun Mo, Yunfeng Huang, Yueyan Huang — Thu, 16 Oct 2025 13:25:55 +0800

Helicobacter pylori (Hp) is a bacterium present in the pyloric region of the human stomach, which can cause gastrointestinal diseases such as gastritis and peptic ulcers. In addition, studies have found that it may be related to some extra-gastrointestinal diseases. This article will review the research progress on the mechanism of Helicobacter pylori in extra-gastrointestinal diseases in children.

Innovation in the “Basic-Clinical” Connection Teaching Model of Biochemistry Course Empowered by AI Case-Guided Learning System

Yungang Shi, Meixia Jia, Changfeng Wang — Thu, 16 Oct 2025 13:33:41 +0800

Against the background of the continuous reform in medical education, biochemistry, as a fundamental medical course, maintains a close connection with clinical practice. However, under the traditional teaching model, the effectiveness of the “basic-clinical” connection is relatively poor, which hinders the improvement of educational outcomes. In the practical teaching of higher vocational medical education, the integration of the AI Case-Guided Learning System can enhance students’ enthusiasm for knowledge exploration and effectively improve teaching quality. Starting from the perspective of the “basic-clinical” connection teaching in the biochemistry course, this paper analyzes the application value of the AI Case-Guided Learning System and proposes specific application strategies, aiming to accumulate experience for the innovation of biochemistry teaching.

Paradigm Shift: Construction of the “One-on-One” Teaching Model in Nursing Education for Neurology Nursing Students

Youxian Tan, Yu Huang, Li Mo, Xianying Tang — Thu, 16 Oct 2025 13:47:34 +0800

With the continuous improvement of the medical industry’s requirements for the professional capabilities of nursing talents, traditional nursing teaching models can hardly meet the needs of complex nursing work in neurology. This paper focuses on nursing education for neurology nursing students and explores the construction of the “one-on-one” teaching model, aiming to achieve a paradigm shift in nursing education. By analyzing the current status of neurology nursing education, this paper identifies the problems in traditional teaching models. Combining the advantages of the “one-on-one” teaching model, it elaborates on the construction path of this model from aspects such as the selection and training of teaching instructors, the design of teaching content, the innovation of teaching methods, and the improvement of the teaching evaluation system. The research shows that the “one-on-one” teaching model can significantly enhance nursing students’ mastery of professional knowledge, clinical operation skills, communication skills, and emergency response capabilities, as well as strengthen their professional identity and sense of responsibility. It provides an effective way to cultivate high-quality nursing talents who can meet the needs of neurology nursing work and promotes the innovative development of nursing education.

Analysis of the Clinical Efficacy of Recombinant Human Interferon α2b Nebulization Inhalation in the Treatment of Hand, Foot, and Mouth Disease in Children

Xia Yang — Thu, 16 Oct 2025 13:57:56 +0800

This clinical study aimed to explore the therapeutic effect of recombinant human interferon α2b nebulization inhalation in the treatment of hand, foot, and mouth disease in children. Sixty-six patients were selected as the research subjects by the random sampling method and divided into a control group and an observation group. The patients in the control group were treated with ribavirin injection and oral lysine-inositol-vitamin B12 solution, while the patients in the observation group received the treatment of the control group combined with recombinant human interferon α2b nebulization inhalation. The clinical effects of the two groups were compared to determine the clinical efficacy of the two treatment plans. The total effective rates of treatment were 78.79% in the control group and 90.91% in the observation group. The research confirmed that the clinical effect of recombinant human interferon α2b nebulization inhalation in the treatment of hand, foot, and mouth disease in children is remarkable. It can significantly improve the symptoms of children with hand, foot, and mouth disease and is suitable for clinical application and promotion.

Exploration on Ideological and Political Education in Preventive Medicine Courses under the Background of “Healthy China” Strategy

Hao He, Ling Chen, Yufen Cui — Thu, 16 Oct 2025 14:07:02 +0800

Under the background of the “Healthy China” strategy, preventive medicine courses shoulder the responsibility of cultivating students’ health literacy and strengthening their sense of social responsibility. As a key part of education in the new era, ideological and political education in courses should not only focus on knowledge transmission but also emphasize the integration of ideological and political education. By exploring the implementation path of ideological and political education in preventive medicine courses under the “Healthy China” strategy, this paper proposes the organic combination of course content and ideological and political education, focusing on how to integrate socialist core values into teaching, and enhance students’ health awareness, social responsibility, and national identity.

Application Effect of Clinical Pathway of Orthopedic Nursing in Patients with Ankle Fracture

Jing Yang — Thu, 16 Oct 2025 14:12:24 +0800

Objective: This study investigates the effect of orthopedic nursing in patients with ankle fractures. Methods: A total of 84 patients with ankle fractures treated in our hospital from September 2022 to September 2023 were selected and randomly divided into a control group and an observation group using a random number table, with 42 cases in each group. The control group received routine nursing, while the observation group received orthopedic nursing clinical pathway on the basis of traditional nursing. We analyzed and scored the nursing satisfaction and nursing effect of the two groups. Results: Compared with the control group, the observation group had a higher total nursing satisfaction rate, shorter time to get out of bed, shorter hospital stay, and lower hospitalization cost. The Barid score and AOFAS score of the observation group were higher than those of the control group, while the NRS score was lower. Conclusion: The application of orthopedic nursing clinical pathway in patients with ankle fractures significantly improves their quality of life, promotes better recovery of ankle function, and shortens the rehabilitation time.

Effective Application of Evidence-Based Nursing in Cancer Pain Care for Tumor Patients

Fangqin Yang — Thu, 16 Oct 2025 14:17:55 +0800

With the aging of China’s population, tumors have become a major disease affecting people’s normal life. In particular, “cancer pain” caused by tumors has a severe impact on tumor patients, not only reducing their quality of life but also exerting negative effects on their physical and mental health and emotions. Therefore, in the clinical care of tumor patients, helping them relieve “cancer pain” and improving the quality and efficiency of medical care services have become important research topics. This paper takes evidence-based nursing as the starting point, analyzes the basic concepts and practical characteristics of evidence-based nursing, and then proposes the application process and effects of evidence-based nursing in cancer pain care for tumor patients.

Nursing Practice of Successful Treatment for an Elderly Patient with Fulminant Myocarditis Using ECMO Combined with IABP

Meng Chen, Liping Fan — Thu, 16 Oct 2025 14:24:23 +0800

This paper summarizes the nursing experience of a 65-year-old elderly patient with fulminant myocarditis complicated by cardiogenic shock who received veno-arterial extracorporeal membrane oxygenation (V-A ECMO) combined with intra-aortic balloon pump (IABP) support therapy. The core nursing measures included: establishing a multidisciplinary collaboration team to implement daily goal management; standardized anticoagulation monitoring; refined hemodynamic management; stepped respiratory support; and early rehabilitation intervention. After 9 days of ECMO support combined with 5 days of IABP support, the patient’s cardiac and respiratory functions recovered. The patient was discharged on the 42^nd day and was fully recovered during the follow-up on the 60^th day. This case suggests that refined nursing care for ECMO combined with IABP is the key to the treatment of fulminant myocarditis.

An Analysis of the Theory and Treatment of Insomnia in Wu Cheng’s Bu Ju Ji

Chengzhi Chu, Zheng Zhao — Thu, 16 Oct 2025 14:34:46 +0800

This paper conducts an in-depth analysis of the theory and methods for differentiating and treating insomnia in Bu Ju Ji by Wu Cheng, a physician of the Qing Dynasty. By systematically sorting out the origin of Wu Cheng’s academic thoughts, this study explores his unique perspective on differentiating and treating insomnia, analyzes the compatibility rules of his core formulas and herbs, and reveals the characteristics of his medication use as well as its guiding value for later clinical practice. Research shows that Wu Cheng integrated the principles of the I Ching (Book of Changes) with medical theories to construct a theoretical system for consumptive diseases. In the differentiation and treatment of insomnia, he emphasized the dynamic balance of zang-fu organs, Qi, blood, Yin and Yang, with special attention to the impact of spleen-Yin deficiency on insomnia. He thus formed distinctive academic features, including treating both deficiency and excess, taking into account both Qi and blood, and regulating the spleen to protect the body’s defense system. In terms of medication, he was skilled in using herbs that are sweet and warm in nature for tonification, harmonizing Qi and blood, and invigorating the spleen to nourish Yin. These insights hold significant reference value for modern TCM (Traditional Chinese Medicine) in the treatment of insomnia.

Study on Nursing Measures of Abdominal Distension in Patients after Endoscopic Polypectomy

Min Hu — Thu, 16 Oct 2025 14:39:49 +0800

Endoscopic polypectomy (EP) is the preferred method for the treatment of rectal polyps because of its micro-trauma and rapid recovery. However, the incidence of postoperative abdominal distension can reach 15–30%. This common complication seriously affects the quality of life of patients after surgery, prolongs the length of hospital stay, and may even be complicated by perforation and other problems. This article systematically reviews the latest research progress on the mechanism, related influencing factors and targeted nursing interventions of abdominal distension after EP, so as to explore effective interventions for postoperative comprehensive nursing, which has core value for improving the postoperative experience and prognosis of EP patients.

Study on the Impact of Network Information Management on the Compliance of Maintenance Hemodialysis Patients

Chunyan Liu, Xuebao Liu — Thu, 16 Oct 2025 00:00:00 +0800

This study focuses on the management of maintenance hemodialysis (MHD) patients, with a specific emphasis on the practical application effect of the network information management model including its impact on patients’ compliance. A network information management model for MHD patients was constructed around three management schemes: “software reminders + follow-up guidance”, “dietary records + self-management reminders”, and “dialysis plan + precise weight management”. These schemes were respectively used to optimize anemia management, control the risk of hyperphosphatemia, and improve toxin clearance efficiency. A controlled experiment was conducted, with an experimental group and a control group set up for comparative practice. The results showed that the network information management model can effectively improve patients’ anemia, help alleviate mineral metabolism disorders and the accumulation of small-molecule toxins, and exert a positive impact on patients’ treatment compliance.

Evaluation on the Application Effect of Humanistic Care in the Nursing of Hemodialysis Patients

Xiaoqing Luo, Ningning Li, Xiju Song, Li Cui — Thu, 16 Oct 2025 00:00:00 +0800

This paper explores the application effect of humanistic care in the nursing of hemodialysis patients. Firstly, it expounds the application value of humanistic care in the nursing of hemodialysis patients. Then, it evaluates the effect by constructing an evaluation index system and combining with empirical analysis. Finally, it puts forward specific application measures and draws conclusions. The purpose is to provide reference for improving the nursing quality of hemodialysis patients, so as to enhance patients’ quality of life and promote their physical and mental health.

Prevention and Care of Common Gynecological Diseases

Yonglan Luo — Thu, 16 Oct 2025 15:03:23 +0800

Objective: To analyze common gynecological diseases in women and explore effective preventive health care, treatment, and nursing measures. Methods: A total of 1,025 women who participated in gynecological disease screening at the gynecological outpatient department of our hospital from January to December 2024 were selected as the research subjects. Among them, 252 patients diagnosed with gynecological diseases were included in the observation group, and the remaining 773 healthy women were included in the control group. The detection status of gynecological diseases and related risk factors were analyzed. Results: Through screening, the common gynecological diseases included vaginitis, uterine fibroids, ovarian cysts, and menstrual disorders. Women aged 40–49 years were the high-risk group for gynecological diseases. Conclusion: The risk of gynecological diseases in women is gradually increasing. It is necessary to strengthen the popularization of knowledge about gynecological diseases among women and guide them to take effective preventive health care, treatment, and nursing measures to reduce their risk of developing gynecological diseases.

A Study on the Professional Competence of Elderly Caregivers under the Integration of Medical and Elderly Care Services

Dan Wang — Thu, 16 Oct 2025 15:08:41 +0800

Against the backdrop of the accelerated aging of the population, the elderly care model integrating medical and elderly care services has become a crucial approach to addressing the challenges of elderly care. As direct providers of integrated medical and elderly care services, the professional competence of elderly caregivers directly affects the quality of services and the quality of life of the elderly. This paper aims to conduct an in-depth study on the professional competence of elderly caregivers under the integrated medical and elderly care model. Firstly, it clarifies the components of elderly caregivers’ professional competence, analyzes the existing problems in their current professional competence, and proposes targeted improvement strategies. The purpose is to build a high-quality and professional team of elderly caregivers, provide strong support for the development of the integrated medical and elderly care cause, and promote the professionalization of integrated medical and elderly care services.

Research Status of Job Satisfaction among Obstetric Nurses

Shan Wang, Zhihua Tan — Thu, 16 Oct 2025 15:15:01 +0800

This paper analyzes the current research status of job satisfaction among obstetric nurses at home and abroad, including research methods, influencing factors, correlation relationships, and countermeasures to improve job satisfaction of obstetric nurses. It aims to provide a reference for subsequent studies on job satisfaction of obstetric nurses.

Research on Transitional Care for Elderly Patients with Chronic Diseases

Xiaoqing Wu — Thu, 16 Oct 2025 15:39:17 +0800

Objective: To explore the application effect of continuous nursing in elderly patients with chronic diseases. Methods: A total of 100 elderly patients with chronic diseases were selected and randomly divided into experimental group and control group, 50 cases in each group. Patients in the experimental group received continuous nursing, while patients in the control group received routine nursing. Comparison of two groups of patients’ quality of life, health and nursing satisfaction. Results: the patient’s quality of life, health and nursing satisfaction were significantly higher than control group (p < 0.05). Conclusion: Continuous nursing has a significant application effect in elderly patients with chronic diseases, which is worthy of further promotion and application.

Methimazole-induced Acute Kidney Injury during the Initial Treatment for Graves’ Disease: a Rare Case Report and Literature Review

Xiaohan Zhai, Hongyan Shi, Xiang Li, Aihong Wang, Bin Wang — Wed, 22 Oct 2025 08:37:10 +0800

As a commonly used oral drug for the treatment of hyperthyroidism, methimazole has common adverse reactions such as a granulocytopenia, thrombocytopenia, arthralgia, skin allergy, etc. The reports of kidney injury caused by methimazole are rare, and the clinical understanding is insufficient, so it is easy to misdiagnosis. This paper reports a middle-aged male patient who was diagnosed with hyperthyroidism in our hospital and developed acute kidney disease after treatment with methimazole. Creatinine and kidney injury-related protein levels decreased after treatment with methimazole. After the primary disease was excluded, acute kidney injury caused by methimazole was highly suspected. The aim of this paper is to improve the safety of methimazole and reduce the rate of missed diagnosis and misdiagnosis.

Standardized English Translation of Clinical Medicine Disease Names

Hongchuan Zhang, Xuan Tang — Fri, 17 Oct 2025 09:21:38 +0800

With the increasing frequency of global medical exchanges, the English translation of clinical medicine disease names has become a key factor affecting medical safety, the quality of academic exchanges, and the level of medical education. Meanwhile, there are certain problems in the English translation of clinical medicine disease names in China currently, mainly manifested in the prevalence of multiple translations for one term, prominent issues of literal translation and mistranslation, and inconsistent naming principles. Based on this, this paper focuses on the strategies for standardized English translation of clinical medicine disease names. By explaining the root causes of the problems existing in the current translation field, it further puts forward standardized suggestions from aspects such as establishing authoritative reference standards, following the basic principles of “respecting the originator, following conventions, and adhering to scientific norms”, strengthening medical English education, and using modern tools to assist learning. These efforts aim to gradually unify and standardize disease names, reduce ambiguities and errors, and lay a foundation for international medical exchanges and evidence-based medical research.

Study on the Current Status and Influencing Factors of Depression in Perinatal Women

Dandan Zhou, Yanhui Liu — Fri, 17 Oct 2025 09:27:37 +0800

Depression is the most common mental disorder among perinatal women, with its incidence showing an annual increasing trend. Depression poses severe harms to the health of mothers and infants, thus requiring high attention from perinatal women themselves, their families, and society. Studies have shown that there are numerous influencing factors for depression in perinatal women, the most common of which include place of residence, monthly family income, recent appetite, mother-in-law and daughter-in-law relationship, personal history of anxiety and depression, obstetric complications during pregnancy, fear of childbirth, utilization of support, positive coping, and susceptible personality. Based on empirical research, this paper conducts an in-depth study and discussion on the current status of depression and its influencing factors in perinatal women, aiming to provide a basis for formulating scientific and effective preventive and intervention measures, and to contribute modestly to effectively reducing the adverse impact of depression on the physical and mental health of mothers and infants.

Research on the Supply Mechanism of Palliative Care Multidisciplinary Teams from the Perspective of Pluralistic Synergy Theory

Xinyan Zhang, Yinyin Lv, Guijun Lu, Peng Yue, Jinxia Liu — Fri, 17 Oct 2025 09:35:26 +0800

Objective: To explore the experiences of palliative care multidisciplinary teams from the perspective of pluralistic synergy theory, aiming to enhance team collaboration. Method: Utilizing a qualitative research methodology, we conducted in-depth interviews with 15 palliative care team members to collect data. Results: The operational framework of palliative care multidisciplinary teams under pluralistic synergy theory involves: enhancing collaboration among team members; developing a comprehensive management model for the team; rationalizing the allocation of work tasks and durations; improving team communication and interaction through effective communication mechanisms and platforms; cultivating skilled professionals; and establishing a robust health record management system. Conclusion: The operational mechanism, informed by pluralistic synergy theory, advances the development of palliative care.

Overview of Studies on Ye Tianshi’s Academic Thoughts in Differentiating and Treating Lung-System Diseases

Ziwei Wang, Shikun Yu — Thu, 16 Oct 2025 15:21:58 +0800

Ye Tianshi was a renowned expert in classical formulas during the Qing Dynasty. He created the Light Bitterness and Mild Pungency Method, which is formulated based on the compatibility of “Xing (bitter almond), Kou (Fructus amomi rotundus), Ju (tangerine peel), and Jie (platycodon root)”. This method regulates the dispersion and descent of lung Qi to dispel warm-heat pathogens and smooth the Qi movement of the triple energizer. In the treatment of lung system diseases, Ye classified them into two major categories based on etiology and pathogenesis: excess syndrome of nutrient-defense and deficiency syndrome of nutrient-defense. When discussing the treatment of cough caused by phlegm-fluid retention, he frequently referred to Synopsis of the Golden Chamber and attached great importance to summarizing and absorbing the academic thoughts of predecessors. As an accomplished expert in classical formulas, Ye Tianshi followed the academic essence of Xuanyuan and Qi Bo (founders of TCM theory) and respected the principles of Zhang Zhongjing’s classical formulas, integrating these theories in a coherent manner. With his masterful application of classical formulas to achieve remarkable curative effects, Ye’s academic viewpoints on treating lung system diseases still exert a profound influence on the modern clinical diagnosis and treatment of related diseases.

Application of Brain-Computer Interface in the Treatment of Mental Illness

Yuda Song, Caiyi Yang, Peichen Yu — Thu, 16 Oct 2025 15:31:16 +0800

Traditional psychological treatment methods often require a long time and have limited effects. Researchers have begun to explore the combination of brain-computer interface (BCI) technology and mental health, providing new possibilities for the treatment and rehabilitation of mental illnesses. This paper reviews the advantages, existing risks, and challenges of BCI technology in mental health treatment, and prospects the future development of research on BCI and mental health.

Analysis of Rehabilitation and Nursing Measures for Patients after Percutaneous Coronary Intervention

Jianhua Li, Jufang Ji — Fri, 17 Oct 2025 08:43:42 +0800

Coronary intervention is an important method for the treatment of coronary heart disease, which can improve the myocardial blood supply function of patients to a great extent. The nursing and rehabilitation after coronary intervention are very important for patients. In view of this, this article analyzed the rehabilitation and nursing of patients after coronary intervention, and put forward some strategies, only for the reference of colleagues.

Application Effect of Problem-Based Learning Combined with DOPS Evaluation Model in Standardized Nurse Training

Wenjun Liang — Fri, 17 Oct 2025 08:48:35 +0800

With the continuous development of the nursing discipline, standardized nurse training has always been a crucial link in the development of nursing science and plays an irreplaceable role in talent cultivation. However, in the current standardized training for some nurses, there are problems such as the simplification of nursing skill evaluation models and insufficient post competence of nurses. Therefore, optimizing the training model for nursing talents has become an inevitable measure. The problem-based learning (PBL) method and the Direct Observation of Procedural Skills (DOPS) evaluation model provide new directions and guidance for the development of training. Against this background, this paper explores effective approaches for standardized nurse training, starting from basic concepts and gradually delving into specific practical paths, aiming to improve the quality of talent cultivation and provide valuable references for other researchers.

Practical Application and Development of Digital Technology in Prosthodontics

Sitong Lu — Fri, 17 Oct 2025 08:53:16 +0800

The application of digital technology in prosthodontics not only improves the accuracy of restoration and the efficiency of diagnosis and treatment, but also brings more comfortable and convenient diagnosis and treatment experience to patients. It effectively promotes the rapid development of the prosthodontic aesthetics industry and leads prosthodontic technology to gradually enter a new digital era. Combining the advantages of digital technology in prosthodontics, this paper focuses on the specific applications of digital impression technology, CAD/CAM technology, network-based integrated cloud service technology, and CBCT technology in prosthodontics. On this basis, it prospects the development trend of digital technology in the field of prosthodontics, aiming to provide solid theoretical and practical support for clinical practice of prosthodontics and promote the gradual integration of the prosthodontic industry with the digital era.

Clinical Effect of Improved Incision in Extraction of Impacted Mandibular Wisdom Teeth

Shanshan Ren — Fri, 17 Oct 2025 09:14:54 +0800

Objective: To explore the clinical effect of improved incision in the extraction of impacted mandibular wisdom teeth. Methods: 160 patients who were treated in our hospital from October, 2024 to April, 2025 and had their mandibular impacted wisdom teeth removed according to the doctor’s advice were randomly divided into observation group and control group. The observation group used modified incision, while the control group used traditional triangular incision. The operation time, intraoperative visual analogue scale (VAS) pain score, pain VAS score on the 1^st, 2^nd and 3^rd day after operation, facial swelling on the 2^nd day after operation, mouth opening limitation on the 2nd day after operation and the incidence of dry socket after operation were recorded and compared between the two groups. Results: There was no significant difference in operation time between the two groups (p > 0.05). The VAS score of pain in the observation group was significantly lower than that in the control group at each time point during and after operation (p < 0.05). On the second day after operation, the facial swelling and mouth opening limitation in the observation group were significantly lighter than those in the control group (p < 0.05). The incidence of dry socket in the observation group was 1.25% (1/80), which was significantly lower than that in the control group (8.75%, 7/80), and the difference was statistically significant (p < 0.05). Conclusion: The application of modified triangular incision in the extraction of impacted mandibular wisdom teeth can effectively relieve the pain during and after operation, reduce postoperative facial swelling and mouth opening limitation, and reduce the incidence of dry socket.

Clinical Significance of Real-Time Two-Dimensional Shear Wave Elastography (SWE) in Assessing Liver Parenchymal Stiffness for Predicting the Severity of Non-Alcoholic Fatty Liver Disease (NAFLD)

Jiayi Ma, Qinyi Qian — Fri, 17 Oct 2025 00:00:00 +0800

Objective: To evaluate the value of real-time two-dimensional shear wave elastography (SWE) in predicting liver parenchymal stiffness in non-alcoholic fatty liver disease (NAFLD). Methods: A total of 200 NAFLD patients (70 in the mild group, 70 in the moderate group, and 60 in the severe group) and 60 healthy individuals (control group) who visited the hospital from December 2023 to December 2024 underwent real-time two-dimensional SWE examinations. Results: Except for high-density lipoprotein, comparisons of body mass index and biochemical indicators showed that the severe group > moderate group > mild group > control group, with P < 0.05. Comparisons of liver stiffness values also showed that the severe group > moderate group > mild group > control group, with P < 0.05. Pearson correlation analysis revealed a positive correlation between liver stiffness values and body mass index, triglycerides, total cholesterol, low-density lipoprotein, fasting blood glucose, and glycosylated hemoglobin. Analysis of the ROC curve indicated that the AUC, standard deviation, and P-value for liver stiffness values were 0.901, 0.025, and 0.01, respectively, suggesting that liver stiffness values can predict the severity of NAFLD. Conclusion: The real-time two-dimensional shear wave elastography (SWE) technique for diagnosing NAFLD can differentiate between NAFLD patients and healthy individuals, as well as determine liver parenchymal stiffness, thereby assisting physicians in quantifying the degree of fatty liver.

Study on the Prognostic Prediction Model and Clinical Application Value of Machine Learning-based Approach for Septic Children in PICU

Li Yu — Thu, 16 Oct 2025 00:00:00 +0800

Objective: To explore the application value of a machine learning-based prediction model in assessing the prognosis of septic children in the pediatric intensive care unit (PICU) and provide data support for clinical decision-making. Methods: A total of 180 septic children admitted to the PICU of a tertiary hospital from January 2020 to December 2024 were selected. They were divided into a control group (90 cases, using traditional scoring methods to predict prognosis) and an observation group (90 cases, using a multivariable model based on machine learning algorithms to predict prognosis) according to the random number table method. General information, laboratory indicators, and clinical interventions were collected. Various models such as Random Forest (RF), Support Vector Machine (SVM), and Logistic Regression (LR) were established. The model performance was evaluated using ROC curve, AUC value, accuracy, sensitivity, and specificity. Results: The machine learning models performed better than traditional scoring methods in predicting the 28-day mortality rate of septic children. Among them, the RF model achieved an AUC value of 0.921, a sensitivity of 85.6%, and a specificity of 88.1%, which were significantly higher than the PIM3 score (AUC 0.762). The prediction accuracy and timeliness of clinical intervention in the observation group were significantly improved, leading to a shortened hospital stay and reduced mortality rate (p < 0.05). Conclusion: The prediction model based on machine learning can more accurately assess the prognostic risk of septic children in PICU, showing good clinical application prospects and providing references for individualized treatment and optimal resource allocation.

Design of Application of Peer Instruction in Nursing Education for Dialysis Patients

Shilin Zou, Qiuhong Yan, Juan Huang, Huiqin Tao, Jianmin Chen — Thu, 16 Oct 2025 00:00:00 +0800

The long-term quality of life of dialysis patients is closely linked to their self-management abilities, such as fluid intake control, medication compliance, and fistula care. Traditional health education models for dialysis patient care, characterized by one-way instruction and a lack of interaction, often result in low patient compliance and inadequate knowledge acquisition. Peer instruction, as a patient-centered educational strategy, leverages the emotional resonance of “shared experiences” and the demonstrative effect of peers, and has been proven effective in improving self-management behaviors among chronic disease patients. This study focuses on the dialysis patient population, integrating clinical practice and technological innovation to deeply analyze the application pathways, effectiveness, and challenges of peer instruction. It aims to provide new ideas and methods for enhancing the quality of nursing education for dialysis patients, thereby improving their knowledge acquisition, self-care abilities, treatment compliance, and overall quality of life.

The Role of Endoscope Diagnosis and Treatment Center Traceability System in Quality Control of Endoscope Cleaning

Na Zhao, Fengjuan Wang — Thu, 16 Oct 2025 16:34:13 +0800

As the cornerstone of sterile instrument maintenance in endoscopy centers, the quality of endoscope cleaning directly impacts hospital infection control effectiveness. The traceability system for endoscopy centers utilizes digital means to document the entire cleaning process, enabling real-time monitoring and precise quality control. This paper analyzes current quality control practices in endoscope cleaning and addresses existing challenges. It explores how traceability systems standardize procedures, enhance monitoring, and improve management efficiency. The study proposes optimization strategies for traceability system implementation, clarifying its core value in endoscope cleaning quality control. These findings provide theoretical foundations and practical guidance for hospitals to refine management of endoscopy centers, ensure diagnostic safety, and reduce infection risks, ultimately advancing endoscope cleaning quality control toward standardized and informatized development.

Application Research on the Strategy of Serious Game Teaching Method to Improve the Clinical Ability of Nursing Students in Neurosurgery Internship

Haiying Xue — Thu, 16 Oct 2025 16:39:16 +0800

Neurosurgical patients present complex clinical conditions with high nursing risks. Under traditional teaching models, nursing interns often exhibit challenges such as weak clinical reasoning, insufficient reflective capabilities, and inadequate operational proficiency, which fail to meet clinical nursing demands. This study focuses on neurosurgical nursing interns as research subjects, systematically exploring the application value and implementation pathways of serious game pedagogy in cultivating clinical competencies.

Readiness for Independent Self-Care and Self-Management among Middle-Aged Patients with Type 2 Diabetes Mellitus

Minjie Gao, Francisco Obmerga — Thu, 16 Oct 2025 17:00:24 +0800

Diabetes is a common chronic disease in clinical practice. The current global average prevalence is 2–6%, and more than 90% of patients have type 2 diabetes. Although there is a correlation between independent self-care and self-management, improving patients’ self-care and self-management behaviors can effectively improve patients’ quality of life. This study aimed to determine if a significant relationship exists between independent self-care and self-management. This study used a quantitative research design. The inclusion criteria included 198 participants using purposeful sampling. This study adopted a correlational research design to determine the association between self-care readiness (independent variable) and self-management (dependent variable). This study surveyed respondents using a three-part questionnaire, and their scores were recorded using the Demographic Profile Questionnaire, Transition Readiness Assessment Questionnaire (TRAQ), and Diabetes Self-Management Questionnaire (DSQM). The data were analyzed using statistical tools such as frequency, percentage, mean, standard deviation, Pearson R and hypothesis testing. The results showed a correlation between independent self-care and self-management in diabetic patients. These findings indicate that the respondents generally reported moderate to high levels of readiness and self-management, with more variability noted in self-management scores. Overall, the findings suggest that preparedness for independent self-care plays a statistically significant role in influencing self-management, although the strength of this relationship is relatively weak.

Research Progress on Nursing Interruptions in the Operating Room

Yajing Ling, Mingming Wang, Renmin Zhang, Shuting Tang, Yan Chen, Peng Wang — Thu, 16 Oct 2025 17:10:26 +0800

In recent years, research on nursing interruptions has been conducted at various levels in emergency departments, intensive care units, hemodialysis centers, operating rooms, and sterilization and supply centers. Nursing interruptions are closely related to adverse nursing events, and interruptions in operating room nursing can significantly impact the success of a patient’s surgery. However, there is a lack of in-depth theoretical research on safety risk assessment and response decision-making by operating room nurses when faced with nursing interruptions. This article reviews the concept, current status, and impact of nursing interruptions in the operating room, analyzes the cognitive level, coping strategies, and negative emotions of operating room nurses, and elaborates on management strategies to provide references for research and management of nursing interruptions in the operating room.

The Effect of Occupational Protection Training on Disinfection Supply Center Personnel on Reducing the Risk of Nosocomial Infection

Fengjuan Wang, Na Zhao — Fri, 17 Oct 2025 08:38:10 +0800

As the core department in medical institutions responsible for cleaning, disinfecting, sterilizing, and supplying reusable medical devices, instruments, and items, the quality of work in the disinfection supply center directly impacts medical safety and infection control effectiveness. Professional protective training for personnel is crucial to ensure operational quality in this department. Systematic training enhances staff awareness of occupational exposure risks, standardizes protective measures in procedures, reduces cross-infection risks caused by improper operations, and ultimately lowers infection transmission risks. This paper analyzes the core content, implementation approaches, and practical role of professional protective training for disinfection supply center personnel in infection control. It aims to clarify the significant value of such training, providing references for medical institutions to optimize disinfection center management and strengthen infection control systems, thereby contributing to improved overall medical safety standards.

Analysis of the Effect of Nursing Based on the Theory of Gratitude Extension-Construction on Improving Hope Levels in Postoperative Breast Cancer Patients

Na Jin — Thu, 16 Oct 2025 15:51:13 +0800

Objective: To explore the practical effectiveness of nursing intervention based on the theory of Gratitude Extension-Construction in improving the sense of hope in breast cancer patients. Methods: A total of 104 breast cancer patients treated in our hospital from January 2023 to May 2024 were included and divided into a control group (routine nursing, 52 cases) and an observation group (routine nursing + nursing based on the theory of Gratitude Extension-Construction) using a random number table method. The Benefit Finding Scale (BFS), Hope Level Scale (HHI), and Quality of Life Questionnaire-Core 30 (QLQ-C30) were used to compare and analyze the scores of the two groups before intervention, 3 months after intervention, and 6 months after intervention. Results: There was no statistically significant difference in BFS, HHI, and QLQ-C30 scores between the two groups before intervention (P > 0.05). Both BFS and HHI scores increased in the two groups at 3 and 6 months after intervention compared to before intervention (P < 0.05), and the observation group had better BFS and HHI scores compared to the control group (P < 0.05). Before intervention, there was no significant difference in QLQ-C30 scores between the two groups in all dimensions (P > 0.05). Data comparison at 6 months after intervention showed that the observation group had better scores in all dimensions of QLQ-C30 than the control group (P < 0.05). Conclusion: Nursing intervention based on the theory of Gratitude Extension-Construction can effectively improve the benefit-finding ability of postoperative breast cancer patients, enhance their level of hope, and improve their quality of life. It is worthy of promotion and application in clinical nursing.

Effect of Hydrogen-rich Atomic Water on Eye Fatigue

Nanxing Ma — Fri, 17 Oct 2025 00:00:00 +0800

This study investigated the effect of hydrogen-rich atomic water on eye fatigue. The experimental results show that hydrogen-rich atomic water can reduce oxidative stress and inflammatory reaction in the eye, and has a significant improvement effect on myopia and visual fatigue, with high safety and no obvious adverse reactions. The results of myopia and visual fatigue improvement experiment showed that the prevalence of myopia in the control group was 15%, and the prevalence of myopia in the experimental group was 5%. The prevalence of myopia in the experimental group was significantly lower than that in the control group. The ocular symptoms of the experimental group were better than those of the control group in the improvement of fatigue, dry eyes, red blood stains and other symptoms. The patient satisfaction score of the experimental group was 95.5%, which was significantly higher than that of the control group. There were no adverse events such as allergic reactions or skin irritation in the experimental group and the control group during the whole experiment.

Efficacy of Early Enteral Nutrition Therapy in ICU Patients with Respiratory Failure and its Impact on Blood Gas Analysis Indicators

Xiaoyan Liu — Fri, 17 Oct 2025 00:00:00 +0800

Objective: To explore the effectiveness of early enteral nutrition therapy in ICU patients with respiratory failure. Methods: A total of 76 ICU patients with respiratory failure, admitted from May 2024 to May 2025, were included in the study. They were divided into an observation group and a control group using a random number table method, and relevant treatment indicators were compared. Results: The total effective rate in the observation group was higher than that in the control group (p < 0.05). After treatment, the observation group showed superior lung function, organ function, health status, nutritional status, body mass index, and blood gas analysis indicators compared to the control group (p < 0.05). Conclusion: Early enteral nutrition therapy is effective in treating ICU patients with respiratory failure and is beneficial for improving their lung function, nutritional status, and blood gas parameters, making it worthy of promotion.

Effects of CircMGAT5 Downregulation on Invasion and MMP-2 Expression in Ovarian Cancer Cells

Lin Chen, Changfeng Man, Yajie Shen, Songlan Zhao, Yongjing Zhou, Yu Fan — Fri, 17 Oct 2025 13:33:25 +0800

Objective: To elucidate the regulatory effects and mechanisms of circular RNA MGAT5 (circMGAT5) on the invasive ability of human ovarian cancer (OC) cells. Methods: Human OC SKOV-3 cells were transfected with circMGAT5 interference plasmids. The expression level of circMGAT5 was detected by quantitative real-time polymerase chain reaction (qRT-PCR). The proliferation and invasive abilities of cancer cells were determined using soft agar colony formation assay and Transwell assay, respectively. The expression of matrix metalloproteinase-2 (MMP-2) at mRNA and protein levels was detected by qRT-PCR and immunofluorescence, respectively. Results: CircMGAT5 level in the circMGAT5-transfected group was significantly downregulated in a concentration- and time-dependent manner (p < 0.005). Soft agar colony formation assay exhibited that the number of colonies formed in the 6.25, 12.5, and 25.0 nM siRNA groups was significantly reduced in a concentration-dependent manner (p < 0.005). Transwell assay revealed that the number of cells penetrating the filter membrane in the 6.25, 12.5, and 25.0 nM siRNA groups was significantly decreased in a concentration-dependent manner (p < 0.005). qRT-PCR and immunofluorescence results demonstrated that the mRNA and protein levels of MMP-2 in OC cells of the siRNA-transfected group were significantly decreased. Conclusion: circMGAT5 plays an important role in the invasion of OC cells, and its mechanism may be related to the downregulation of MMP-2 expression.

Musculoskeletal Ultrasound Research Over the Past Two Decades (2005–2025): Global Bibliometric and Knowledge Network Analysis

Xiaodi Chen, Zhiyang Lv — Fri, 17 Oct 2025 13:40:15 +0800

Objective: To conduct a comprehensive bibliometric and knowledge network analysis of musculoskeletal ultrasound (MSK US) research from 2005 to 2025, with a focus on publication trends, influential authors, institutions, and thematic hotspots. Methods: Articles related to MSK US were retrieved from the Web of Science Core Collection using the search strategy TS = (“musculoskeletal ultrasound” OR “MSK ultrasound” OR “musculoskeletal ultrasonography”) AND (tendon OR ligament). Eligible studies included English-language original research and review articles published between 2005 and 2025. Bibliometric analyses were performed using VOSviewer and CiteSpace to evaluate publication trends, co-citation networks, author collaborations, institutional and country partnerships, and keyword co-occurrence. Results: A total of 570 articles (476 original research papers and 94 reviews) were included. The annual number of publications increased exponentially, peaking in 2020. Co-citation analysis identified Wakefield (2005), Naredo, and Filippucci as foundational contributors. Author collaboration networks highlighted a strong European core centered on Italy and Spain, while institutional and country analyses revealed a “Europe–North America” dual-center pattern with growing contributions from China. Keyword co-occurrence analysis revealed three main research pillars: inflammatory arthropathies, sports-related injuries, and degenerative conditions, with emerging interest in advanced imaging techniques and artificial intelligence. Conclusion: T MSK US research has demonstrated sustained growth and diversification over the past two decades. Europe remains a traditional leader, but increasing output from North America and Asia reflects a shift toward global, multicenter collaboration. Future research should prioritize methodological standardization, integration of novel imaging technologies, and alignment with clinically meaningful outcomes to optimize diagnostic accuracy and clinical utility.

Analysis of the Disease Burden of Knee Osteoarthritis in China from 1990 to 2021, Attributable Risk Factors, and Predictions for 2035

Weigang Liu, Qian Wu, Heqing Tang — Fri, 17 Oct 2025 13:51:25 +0800

Objective: Knee osteoarthritis is one of the important causes of disability worldwide. This study aims to analyze the disease burden of knee osteoarthritis, attributable risk factors among Chinese residents from 1990 to 2021, and predict the disease burden trend for 2035. Methods: Data related to knee osteoarthritis in China from 1990 to 2021, including the number of incident cases, incidence rate, number of prevalent cases, prevalence rate, and years lived with disability (YLDs), were collected from the Global Burden of Disease Study (GBD2021) database. Joinpoint regression analysis was used to assess time trends, and the Bayesian-Age-Period-Cohort (BAPC) regression model was employed for future predictions. Results: From 1990 to 2021, the number of incident cases of knee osteoarthritis among Chinese residents increased from 3.65 million to 8.51 million, a rise of 133.16%, with an average annual increase of 3.15%. The incidence rate increased from 310.33 per 100,000 to 598.31 per 100,000, a rise of 92.80%, with an average annual increase of 2.55%. The number of prevalent cases increased from 41.04 million to 110 million, a rise of 166.97%, with an average annual increase of 3.61%. The prevalence rate increased from 3488.78 per 100,000 to 7701.69 per 100,000, a rise of 120.76%, with an average annual increase of 3.00%. The number of YLDs increased from 1.34 million to 3.55 million, a rise of 165.32%, with an average annual increase of 3.59%. The YLD rate increased from 113.86 per 100,000 to 249.81 per 100,000, a rise of 119.39%, with an average annual increase of 2.99%. High BMI was the only significant attributable risk factor, with the proportion of YLDs it caused continuing to rise. Predictions for 2035: The number of incident cases is expected to decline slightly from 5.89 million in 2022 to 5.72 million in 2035. The number of prevalent cases is expected to peak at 72.42 million in 2029 and be around 72.69 million in 2035. The number of YLDs is expected to increase year by year, from 2.35 million in 2022 to 2.35 million in 2035. Conclusion: The study reveals the increasing prevalence and disease burden of knee osteoarthritis among Chinese residents, emphasizing the importance of interventions targeting controllable risk factors. Although the prediction shows a slight decline in the number of incident cases in 2035, the number of prevalent cases and years of disability are expected to remain high, indicating the need for continued monitoring and intervention.

Evaluation of the Effectiveness, Accuracy, Specificity, and Sensitivity of High-Frequency Ultrasound in Differentiating Benign and Malignant Breast Micronodules

Danhong Yan, Weimin Li, Hongtao Duan — Fri, 17 Oct 2025 14:02:28 +0800

Objective: To analyze the significance of high-frequency ultrasound in differentiating benign and malignant breast micronodules. Methods: Eighty-five patients with breast micronodules admitted for diagnosis between October 2022 and October 2024 were selected for high-frequency ultrasound diagnosis. The diagnostic efficacy of high-frequency ultrasound was evaluated by comparing it with the results of surgical pathology. Results: High-frequency ultrasound detected 50 benign nodules, primarily breast fibroadenomas, and 35 malignant nodules, mainly breast ductal carcinoma in situ. Based on surgical pathology results, the diagnostic accuracy of high-frequency ultrasound was 96.47%, specificity was 97.96%, and sensitivity was 94.44%. In high-frequency ultrasound diagnosis, the proportion of grade III and IV blood flow in malignant nodules was higher than that in benign nodules, while the proportion of regular shape and clear margins was lower. The proportion of microcalcifications and posterior echo attenuation was higher in malignant nodules, and the resistance index (RI) and peak blood flow velocity were lower than those in benign nodules (P < 0.05). Conclusion: High-frequency ultrasound can effectively differentiate benign and malignant breast micronodules, determine specific nodule types, and exhibits high diagnostic accuracy and sensitivity. Additionally, benign and malignant nodules can be differentiated based on the grading of blood flow signals, sonographic features, and blood flow velocity, providing reasonable guidance for subsequent treatment plans.

Gut Microbiota and Cardiovascular Disease (2005–2025): A Bibliometric and Knowledge-Mapping Analysis

Ying Peng, Ying Yang, Zhiyang Lv — Fri, 17 Oct 2025 14:11:56 +0800

Objective: To quantitatively analyze global research trends on the gut microbiota and cardiovascular disease (CVD) from 2005–2025, identifying publication output, core themes, influential articles, and emerging research hotspots. Methods: We retrieved publications related to gut microbiota and CVD from 2005–2025 using standard bibliographic databases. A bibliometric analysis was conducted to evaluate annual output growth, leading journals, country and institutional contributions, author collaborations, citation networks, and keyword co-occurrence patterns. Descriptive statistics and visualization tools were used to map the developmental trajectory and research hotspots of this field. Results: The analysis included a sharp rise in publications over the past two decades, with especially rapid growth after 2015. Collaborative networks highlighted a few key countries and research centers driving the field. Highly cited papers clustered around themes such as microbiota-derived metabolites such as trimethylamine N-oxide, inflammation, and the “gut-heart axis.” Keyword analysis indicated evolving focus from early descriptive studies to recent mechanistic and clinical translational research. Conclusion: Research linking gut microbiota and CVD has expanded exponentially in 2005–2025, transitioning from correlation studies to mechanistic and therapeutic explorations. The bibliometric trends underscore the gut-heart axis as an emerging interdisciplinary domain in cardiovascular research, with potential to inform novel preventive and therapeutic strategies.

Trends in Occupational Environmental Hazardous Factors and Health Damage: Based on Data from Yangzhou City over Three Years

Faqiang Li, Zhen Li — Fri, 17 Oct 2025 14:23:15 +0800

Objective: To analyze the trends in occupational environmental hazardous factors and health damage, and to assess the degree of occupational health risks. Methods: A total of 1,733 occupational disease monitoring data points from workplaces collected by the Yangzhou Center for Disease Control and Prevention from January 2019 to December 2021 were selected to evaluate occupational hazard factors and occupational health risk levels. Results: Over the three-year period, there were 525 monitoring samples for dust exposure, with an exceedance rate of 1.71% (9/525); 791 monitoring samples for noise exposure, with an exceedance rate of 4.42% (35/791); and 417 monitoring samples for chemical toxins (exogenous) exposure, with an exceedance rate of 1.68% (7/417). A comprehensive evaluation of exceedance factors revealed that high-risk factors included silica dust and benzene, classified as Level 4, while medium-risk factors encompassed manganese and xylene, including their compounds, classified as Level 3. Conclusion: After long-term monitoring of multiple workplaces in the city, it was found that there were certain occupational hazard factors, specifically involving dust or noise, as well as related factors of chemical toxins. Among these, silica dust and benzene posed the highest risks, while manganese and xylene also carried relatively high risks. It is necessary to strengthen occupational disease prevention and management to reduce the occurrence risks.

Research Analysis on Family Caregiving for Infants and Toddlers Aged 6–36 Months in Tianhe District, Guangzhou

Shiqi Zheng, Fengyue Lv, Yaqing Wang, Yalan Liao, Siyi Chen, Zhai Lei — Thu, 16 Oct 2025 10:58:37 +0800

Objective: To understand the current status and influencing factors of family caregiving for infants and toddlers aged 6–36 months in Tianhe District, Guangzhou City, with the aim of better comprehending the physiological and psychological needs of infants and toddlers, and assisting families in developing effective intervention measures and support strategies. Methods: In November 2024, a random sample of 311 infants and toddlers aged 6–36 months from the permanent resident population in Tianhe District, Guangzhou City, was selected. Caregivers were surveyed using a questionnaire regarding family caregiving practices for infants and toddlers. The Kruskal-Wallis’s test, Mann-Whitney test, and multiple linear regression analysis were employed to examine the influencing factors of family caregiving for infants and toddlers. Results: The findings indicate that the quality of family caregiving is significantly influenced by the educational level of the parents (p < 0.001) and the annual household income (p < 0.001). Work-family conflict showed a significant negative correlation with the quality of family caregiving (β = -0.239, p < 0.001), while family atmosphere demonstrated a significant positive correlation with the quality of family caregiving (β = 0.225, p < 0.001). Conclusion: In Tianhe District, Guangzhou City, the quality of infant and toddler caregiving is determined by a combination of key factors, including annual household income, parental educational background, work-family conflict, and family atmosphere. These elements collectively form the core determinants of caregiving practices for infants and toddlers.

Progress in the Epidemiology and Clinical Diagnosis and Treatment of Hepatocellular Carcinoma

Tian Chang, Yuqing Li, Yuanyuan Jia, Yu Cai — Wed, 22 Oct 2025 09:00:22 +0800

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths globally, and its epidemiological characteristics and risk factors are continuously evolving. This review systematically elaborates on the global disease burden of HCC, the main risk factors (including hepatitis B/C virus infection, non-alcoholic fatty liver disease, aflatoxin exposure, and unhealthy lifestyles), and the corresponding prevention strategies. The article provides a detailed analysis of the performance and limitations of key serological markers currently used for early diagnosis of HCC, such as alpha-fetoprotein, abnormal prothrombin, and alpha-fetoprotein variant L3. Furthermore, the review comprehensively summarizes the advancements in clinical treatment for HCC, ranging from radical approaches including surgical resection, liver transplantation, radiofrequency ablation to palliative therapies for patients with advanced disease such as transcatheter arterial chemoembolization, targeted therapy, immunotherapy, and further evaluates their efficacy, indications, and challenges. This article aims to provide a comprehensive reference for a deeper understanding of the current status of HCC prevention and control, improving early diagnostic rates, and optimizing clinical treatment strategies.

Professional Training Boosts Pediatric Nurses' Clown Therapy Perceptions.

Thu, 23 Oct 2025 15:56:01 +0800

Aim: To evaluate the impact of professional training on pediatric outpatient nurses’ cognition and attitudes towards the use of clown therapy, and to assess its clinical applicability. Design: A pre- and post-training evaluation study. Methods: A total of 31 pediatric outpatient nurses participated in the study, completing a self-designed 15-item questionnaire focused on clown therapy. The questionnaires were administered both before and after a structured training program. The assessment aimed to measure changes in nurses’ knowledge and attitudes toward clown therapy. Results: The results indicated a statistically significant improvement in the nurses’ cognition following the training (mean score post-training: 8.55 vs pre-training: 7.71, p = 0.003). Conclusion: Notably, the training also eliminated the age-related differences in cognition observed prior to the intervention. Furthermore, nurses expressed more positive attitudes toward the clinical implementation of clown therapy post-training.