Objective: To assess ultrasound’s ultrasonographic performance and clinical value in diagnosing uterine fibroids. Methods: 60 patients with suspected uterine fibroids admitted to the hospital between March 2021 and March 2024 were selected for this study. Abdominal B-mode ultrasound was used as the gold standard to detect pathological findings, and the results were compared and analyzed. Results: 54 patients were diagnosed after the gold standard, and the results of abdominal B-mode ultrasound were positive predictive value: 96.29%; negative predictive value: 66.67%; accuracy: 93.33%; sensitivity: 96.29%; specificity: 66.67%. Among 60 patients examined by B-mode ultrasound, there were a total of 54 patients who were diagnosed by the gold standard, and 19 cases of uterine leiomyosarcoma were confirmed by the detection of uterine leiomyosarcoma by the gold standard, and B-mode ultrasound (94.73%); 21 cases of cervical leiomyoma were confirmed by gold standard test and 20 cases of cervical leiomyoma were diagnosed by ultrasound (95.24%); 14 cases of mixed leiomyoma were confirmed by gold standard test and 14 cases of mixed leiomyoma were diagnosed by ultrasound (100.00%). Conclusion: Using abdominal ultrasound to examine patients with uterine fibroids can significantly improve the efficiency of diagnosis and treatment and provide a strong scientific basis for subsequent treatment decisions.