Objective: To observe the promotion and application of combined spinal-epidural analgesia with ropivacaine and sufentanil in plateau areas. Methods: Sixty primiparous women who gave birth in our hospital from March 2023 to March 2025 were selected and randomly divided into a control group (Group A) and an analgesia group (Group B) using the random number method. Group A underwent routine obstetric natural childbirth, while Group B received combined spinal-epidural analgesia. VAS scores, changes in labor duration, postpartum hemorrhage, delivery methods (including instrumental delivery), and neonatal Apgar scores were observed in both groups. Results: There was no statistically significant difference in VAS scores between the two groups before analgesia (P > 0.05). However, there were statistically significant differences in VAS scores at various time points after analgesia (P < 0.05). The first stage of labor in Group B (210 ± 45 min) was shorter than that in Group A (252±44 min), with a statistically significant difference (P < 0.05). Similarly, the second (38 ± 11 min vs. 50 ± 14 min) and third (9 ± 4 min vs. 16 ± 5 min) stages of labor were also shorter in Group B compared to Group A, with statistically significant differences (P < 0.05). The cesarean section rate was lower in Group B (6.7%) compared to Group A (10.0%), with a statistically significant difference (P < 0.05). There were no statistically significant differences in postpartum hemorrhage or neonatal Apgar scores at 1, 5, and 10 minutes after birth between the two groups (P > 0.05). Conclusion: The combined use of ropivacaine and sufentanil in combined spinal-epidural anesthesia can significantly alleviate the pain experienced by parturients during childbirth in plateau regions, shorten the duration of labor, and have no effect on the neonatal Apgar score. This method is worthy of promotion in plateau regions.