Given the current situation where professional knowledge and value guidance are not deeply integrated in the ideological and political construction of Internal Medicine Nursing, this paper creates a systematic integration plan for curriculum-based ideological and political education from four aspects: target anchoring, element excavation, method innovation, and effect evaluation, and implements it in teaching. This path precisely identifies the ideological and political distribution nodes of each knowledge module, promotes value internalization through diverse teaching methods, including case discussion, scenario simulation, and clinical practice, and achieves the organic integration of knowledge transmission, ability cultivation, and value shaping through the whole-process connection of pre-class, in-class, and post-class stages and a multi-subject, multi-dimensional evaluation system. Practice has proven that this path effectively enhances students' professional identity and learning motivation, providing a replicable practical model for the implementation and transformation of curriculum-based ideological and political education in nursing specialties.