Expanding Therapeutic Potential and Mechanisms of SIRT3 in Bone-Related Diseases through Mitochondrial Function Regulation

Fei Dou; Taoxian Wang; Rongxin Meng; Cheng Peng; Junxiang Wang; Shengchao Yang; Dinggui Lu

doi:10.26689/bas.v4i3.15354

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7 July 2026

Expanding Therapeutic Potential and Mechanisms of SIRT3 in Bone-Related Diseases through Mitochondrial Function Regulation

Fei Dou, Taoxian Wang, Rongxin Meng, Cheng Peng, Junxiang Wang, Shengchao Yang, Dinggui Lu

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¹ Graduate School, Youjiang Medical University for Nationalities, Baise 533000, Guangxi Zhuang Autonomous Region, China,

² Department of Orthopedic Surgery, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise 533000, Guangxi Zhuang Autonomous Region, China,

BAS 2026 , 4(3), 45–52; https://doi.org/10.26689/bas.v4i3.15354

© 2026 by the Authors. Licensee Whioce Publishing, Singapore. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )

Abstract

As a representative degenerative joint disease, the pathological mechanism of osteoarthritis has increasingly highlighted the critical role of SIRT3 protein in various bone-related disorders. Beyond its significant impact on osteoarthritis, mitochondrial dysfunction is closely linked to the pathogenesis of multiple bone diseases, including osteoporosis, osteonecrosis, bone erosion in rheumatoid arthritis, abnormal fracture healing, and bone tumors. This review systematically explores how SIRT3 regulates mitochondrial function, thereby influencing metabolic processes, apoptosis, autophagy, and senescence in various bone-related cells such as osteoblasts, osteoclasts, osteocytes, and chondrocytes. By conducting cross-disease comparative analysis, we reveal the central role of the SIRT3-mitochondrial function axis in maintaining skeletal homeostasis, providing important theoretical basis and research directions for the future development of broad-spectrum skeletal protection strategies targeting SIRT3.

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