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Volume 4,Issue 3

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26 December 2023
Clinical Efficacy and Safety Analysis of Amisulpride Combined with Venlafaxine in Treating Geriatric Depression
Xing Wu ,  Jin’e Shen ,  Min Zhu
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1 Mental Hospital of Yunnan Province, Kunming 650224, Yunnan Province, China,
2 Mental Hospital of Yunnan Province, Kunming 650224, Yunnan Province, China,
3 Mental Hospital of Yunnan Province, Kunming 650224, Yunnan Province, China,
CNR 2023 , 1(3), 42–46; https://doi.org/10.26689/cnr.v1i3.5861
© 2023 by the Authors. Licensee Whioce Publishing, Singapore. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
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Abstract

Objective: To analyze the therapeutic effect of amisulpride (ASP) combined with venlafaxine (VEN) on depression among the elderly. Methods: 75 elderly patients with depression who were hospitalized between January 2020 and January 2021 were selected and randomly divided into 2 groups: Group A and Group B. The 38 patients in Group A were treated with ASP combined with VEN, and the 37 patients in Group B were treated with VEN. The effects of the two treatments were compared. Results: The treatment in Group A was more effective than Group B (P < 0.05). Before treatment, there was no difference in the depression score and coping mechanisms between the two groups (P > 0.05). After six weeks of treatment, the depression score of Group A was lower than that of Group B, and the coping mechanism score of Group A was higher than that of Group B (P < 0.05). Group A had a lower adverse reaction rate compared to Group B (P < 0.05). Conclusion: ASP combined with VEN therapy is more effective in treating geriatric depression. It improves their symptoms and coping mechanisms, and the drugs used are relatively safe.

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