Clinical Effect of Nimodipine Combined with Rosuvastatin Calcium in the Treatment of Hypertensive Intracerebral Hemorrhage

¹ Department of Neurosurgery, The 960th Hospital of the Joint Logistic Support Force of the Chinese People’s Liberation Army, Jinan 250000, Shandong Province, China,

CNR 2025 , 3(1), 1–7; https://doi.org/10.26689/cnr.v3i1.9877

© 2025 by the Authors. Licensee Whioce Publishing, Singapore. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )

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Abstract

Objective: To explore the clinical effect of nimodipine combined with rosuvastatin calcium in the treatment of hypertensive intracerebral hemorrhage. Methods: Sixty patients with hypertensive intracerebral hemorrhage from January 2023 to December 2023 were randomly divided into a control group (n = 30) and an observation group (n = 30). The control group received conventional treatment, while the observation group was treated with nimodipine + rosuvastatin calcium tablets. The neurological function, edema volume, hematoma volume, adverse reactions, and treatment efficiency were compared between the two groups. Results: After treatment, compared with the control group, the edema volume, hematoma volume index, and NIHSS score in the observation group were all reduced, and the differences were extremely significant (P < 0.001). The clinical efficacy of the observation group was 93.33%, which was much higher than the 66.67% of the control group, and the difference was significant (P < 0.05). The incidence of adverse reactions in the observation group was 3.33%, which was far lower than the 30.00% of the control group, and the difference was significant (P < 0.05). Conclusion: Nimodipine combined with rosuvastatin calcium in the treatment of hypertensive intracerebral hemorrhage shows significant advantages in improving edema volume and hematoma volume, promoting neurological recovery, improving clinical efficacy, and reducing the incidence of adverse reactions, thus having broad clinical application prospects.

References

Li YG, Yang YW, Wang XL, et al., 2023, Comparison of the Efficacy of Soft Channel Hematoma Puncture and Drainage Versus Neuroendoscopic Intracranial Hematoma Removal for the Treatment of Hypertensive Cerebral Hemorrhage. Journal of Practical Medicine, 39(7): 833–837.

Cha Z, Cha HF, 2023, Expression Changes and Clinical Significance of Plasma lncRNA FENDRR and miR-126 in Patients with Hypertensive Cerebral Hemorrhage. Shandong Medical Journal, 63(13): 59–62.

Yuan CC, Shen JZ, Peng MJ, et al., 2023, The Influence of Serum microRNA-130a on Elderly Hypertensive Cerebral Hemorrhage. Chinese Journal of Geriatrics, 43(23): 5643–5645.

Rivera-Lara L, Cho SM, Li Y, et al., 2024, Mechanistic Evaluation of Diffusion Weighted Hyperintense Lesions after Large Spontaneous Intracerebral Hemorrhage: A Subgroup Analysis of MISTIE III. Neurocritical Care, 40(3): 1140–1150.

Gong H, Tan F, Yang DQ, 2023, Implementation Effect of Optimized Health Education Combined with Ecological Nutrition during the Perioperative Period for Patients with Hypertensive Cerebral Hemorrhage. Nursing Practice and Research, 20(2): 255–259.

Tan WF, Hu Q, Huang R, 2023, Analysis of Serum Levels of NF-κB and MIP-1α and their Predictive Value in Patients with Severe Hypertensive Cerebral Hemorrhage Complicated with Postoperative Intracranial Infection. Journal of Nanchang University (Medical Edition), 63(4): 69–72 + 84.

Fang XP, Song DW, Ni M, 2022, Clinical Efficacy of Nifedipine Combined with Rosuvastatin Tablets in the Treatment of Hypertensive Cerebral Hemorrhage. Chinese Journal of Integrative Medicine on Cardio-/Cerebrovascular Disease, 20(8): 1509–1512.

Li SW, Shao XZ, Li L, 2022, The Efficacy of Mouse Nerve Growth Factor Combined with Nimodipine on Neurological Deficit and Serum Inflammatory Factors in Patients with Hypertensive Cerebral Hemorrhage. Trauma & Critical Care Medicine, 10(1): 16–19 + 39.

Huang JH, Jia H, Li FH, et al., 2022, Therapeutic Effect of Sodium Aescinate in Hypertensive Cerebral Hemorrhage and its Influence on Serum GM-CSF and HMGB-1. Chinese Journal of Integrative Medicine on Cardio-/Cerebrovascular Disease, 20(16): 3035–3038.

Chen T, Xu CQ, He SL, 2023, Efficacy and Safety Analysis of Enoxaparin in the Treatment of Hypertensive Cerebral Hemorrhage Complicated with Pulmonary Embolism. Chinese Journal of Lung Diseases (Electronic Edition), 16(5): 679–681.

He SW, Li X, Chen MD, 2023, Clinical Observation of Edaravone Combined with Neuroendoscopy in the Treatment of Hypertensive Cerebral Hemorrhage. China Pharmaceuticals, 32(9): 102–105.

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