Application Status and Prospect of Craniocerebral Ultrasound in Neurodevelopment of Premature Infants

¹ Department of Medical Ultrasound, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan 250013, Shandong, China,

CNR 2025 , 3(2), 70–78; https://doi.org/10.26689/cnr.v3i2.11155

© 2025 by the Authors. Licensee Whioce Publishing, Singapore. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )

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Abstract

The purpose of this paper is to review the current status and future direction of the application of Cranial Ultrasonography (CUS) in the monitoring of brain development in preterm infants. A systematic search of the relevant literature and a comprehensive analysis of the data in these literatures indicate that CUS can provide real-time information about the structural and hemodynamic changes in the brain of preterm infants, which can help to identify neurodevelopmental abnormalities at an early stage, and that the application of new technologies, such as ultrasound elastography, ultrasound microfluidics, and ultrasonography, has further enhanced the assessment capability of CUS. Although the use of artificial intelligence algorithms such as deep learning in monitoring the neurodevelopment of preterm infants is still in its early stages, its promising future in clinical applications is of far-reaching significance. The monitoring of brain development of preterm infants by CUS is effective and accurate, providing more accurate brain development monitoring and more effective treatment programs for preterm infants.

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