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Volume 4,Issue 3

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31 December 2025
Real-world Study of Citicoline on the Neurological Prognosis of Acute and Convalescent Patients with Ischemic Stroke
Yue Qu ,  Yuan Wang ,  Kun Wang ,  Yanhua Zheng ,  Wei Shang
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1 Department of Neurology, The Second Hospital of Shandong University, Jinan 250000, Shandong, China,
2 Department of Neurology, The Affiliated Hospital of Qingdao University, Qingdao 266000, Shandong, China,
3 Department of Neurology, Weifang People’s Hospital, Weifang 261041, Shandong, China,
CNR 2025 , 3(4), 16–23; https://doi.org/10.26689/cnr.v3i4.13342
© 2025 by the Authors. Licensee Whioce Publishing, Singapore. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
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Abstract

Objective: To evaluate the effect and safety of citicoline on the improvement of neurological function in patients with ischemic stroke. Methods: The Mini-Mental State Examination (MMSE) score and National Institutes of Health Stroke Scale (NIHSS) score were analyzed in 8780 patients with ischemic stroke who received citicoline therapy from January 2023 to April 2024 at 1 month, 2 months, and 3 months after treatment. Results: With the prolongation of treatment, the MMSE and NIHSS scores of the patients improved significantly, and the total clinical effectiveness rate at three months was 43.08%. The incidence of adverse reactions was 0.14%, mainly mild gastrointestinal reactions and central nervous system reactions. Conclusion: Citicoline has a significant effect on improving neurological function in patients with ischemic stroke, and its safety is high.

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