Based on the “6S” pyramid evidence model, this study systematically searched and integrated high-quality evidence such as relevant guidelines, expert consensus, systematic reviews, and clinical studies on discharge preparation services for patients with myasthenia gravis (MG) worldwide up to March 27, 2024. A total of 12 literatures were finally included, and 14 best practice recommendations were summarized, covering six key links: assessment within 24 hours of admission, in-hospital services, pre-discharge preparation, discharge-day services, post-discharge follow-up, and effect evaluation. Evidence indicates that a comprehensive assessment should be completed within 24 hours of the patient’s admission, and a multidisciplinary collaborative discharge plan should be initiated. Personalized health education and rehabilitation training should be carried out during hospitalization. Before discharge, patients’ self-management capabilities should be confirmed, and structured discharge guidance should be provided. Post-discharge continuous care should be strengthened through regular follow-up. This can effectively improve patients’ discharge readiness, reduce readmission rates, and provide an evidence-based basis for medical staff to systematically implement discharge preparation services for MG patients and ensure the safety of the transition period.