The Impact of Cerebral Small Vessel Disease on Hemorrhagic Transformation After Mechanical Thrombectomy in Acute Large Vessel Occlusion Ischemic Stroke

Yangyang Wu, Jing Shi, Xuan Chen

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¹ Department of Neurology, Taiyuan Central Hospital, Taiyuan 030000, Shanxi, China,

CNR 2026 , 4(3), 12–23; https://doi.org/10.26689/cnr.v4i3.15721

© 2026 by the Authors. Licensee Whioce Publishing, Singapore. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )

Abstract

With the intensification of population aging and the rapid development of neuroimaging, cerebral small vessel disease (CSVD) has garnered increasing attention. Endovascular thrombectomy (EVT) can significantly improve functional outcomes in patients with intracranial large vessel occlusion and has become the standard treatment for acute large vessel occlusion ischemic stroke. Numerous studies suggest that pre-existing CSVD before acute ischemic stroke may increase the risk of hemorrhagic transformation (HT) after EVT, yet results remain controversial. This article primarily discusses the impact of different subtypes of CSVD and the total burden on magnetic resonance imaging on HT after EVT in patients with acute large vessel occlusion ischemic stroke, aiming to provide a clinical reference.

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