Objective: To investigate the effect of the LEARNS model in the self-management of patients with maintenance hemodialysis and volume overload. Methods: Eighty patients with maintenance hemodialysis and volume overload admitted from September 2022 to May 2024 were selected as the main subjects of this experiment. They were divided into two groups based on the odd or even days of their admission, with 40 patients in each group. Patients admitted on odd days were included in the new group and received LEARNS model education, while patients admitted on even days were included in the traditional group and received traditional education. The self-care ability, treatment adherence, and quality of life were compared between the new group and the traditional group. Results: The self-care ability, treatment adherence, and quality of life of patients with maintenance hemodialysis and volume overload in the new group were significantly higher than those in the traditional group, with statistically significant differences between the groups (P < 0.05). Conclusion: The LEARNS model is more effective in the self-management of patients with maintenance hemodialysis and volume overload, and it is worthy of widespread clinical application.