ARTICLE
Volume 4,Issue 2
30 June 2026
Insulin and Cardiovascular Health: New Insights in the Field of Coronary Heart Disease Complicated with Type 2 Diabetes
Pengfei Yang ,
Shuang Zhang ,
Furong Ming ,
Yaru Zhang ,
Haoran Zhu ,
Yong Cao ,
Cheng Shen
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1
Department of Clinical Medicine, Jining Medical University, Jining 27200, Shandong, China,
2
Department of Cardiology, Affiliated Hospital of Jining Medical University, Jining 27200, Shandong, China; Shandong Provincial Key Medical and Health Discipline of Cardiology, Affiliated Hospital of Jining Medical University, Jining 27200, Shandong, China; Shandong Provincial Key Medical and Health Laboratory of Diagnosis and Treatment of Cardiovascular Diseases, Affiliated Hospital of Jining Medical University, Jining 27200, Shandong, China; Jining Key Laboratory of Precise Therapeutic Research of Coronary Intervention, Jining 27200, Shandong, China,
CR 2026 , 4(2), 75–90;
https://doi.org/10.26689/cr.v4i2.15400
© 2026 by the Authors. Licensee Whioce Publishing, Singapore. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
Abstract
Insulin is currently a crucial treatment for treating type 2 diabetes and plays a significant role in improving the prognosis of patients. When patients with cardiovascular disease who also have type 2 diabetes, the all-cause mortality rate increases by approximately 1.5 times. Consequently, many patients choose insulin as a treatment method for type 2 diabetes. However, the effects and mechanisms of insulin treatment on cardiovascular disease are rarely discussed. This review systematically explores the role and mechanisms of insulin and its related receptors in the progression of cardiovascular disease in patients with both conditions. It focuses on the impact of insulin on coronary plaques, cardiovascular neogenesis, and myocardium, aiming to guide clinical treatment and improve patient outcomes.
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