This paper aims to explore the effect of zygomatic fat pad lifting combined with ultra-high superficial muscular aponeurotic system (SMAS) technique on the improvement of nasolabial folds. From December 2021 to June 2022, 40 patients with facial sagging were selected in our hospital to perform zygomatic fat pad lifting combined with ultra-high SMAS technology for large facelift surgery. Combined with lower eyelid incision and zygomatic fat pad degloving, the middle and lower face lift surgery, the improvement of the nasolabial fold, and the reduction of the apple cheeks were evaluated to assess the surgical effect. Statistics were collected on the improvement of nasolabial folds and apple cheeks aesthetic units before and after operation in 40 follow-up patients, and the satisfaction degree of nasolabial fold elevation and apple cheeks reduction was investigated and analyzed. The facial nasolabial folds and apple cheeks aesthetic units of 40 patients were followed-up after operation and compared with those before operation, and the difference was statistically significant (P < 0.05). After surgical treatment, 95% of patients were satisfied with the improvement of nasolabial folds, and 97.5% were satisfied with the reduction of apple cheeks. Zygomatic fat pad lifting combined with ultra-high SMAS technique has a significant effect on the reduction of apple cheeks zygomatic fat pad and nasolabial fold elevation, and it has clinical application value.