Psoriasis and dermatitis are chronic and troubling skin diseases. To face this challenge, a variety of innovative therapeutic methods came into being. It is necessary to review and summarize the research process of these novel drug therapeutic methods. Local researchers have conducted a comprehensive understanding of the research of traditional medicines, and the research progress of novel therapeutic methods such as biologic drugs and small-molecule targeted drugs has been widely reported. A comprehensive comparison of the new treatments helps to reveal the nuances of each treatment and understand the depth and breadth of its therapeutic effects. New therapeutic approaches, such as cell transplantation, biologic drugs, and small-molecule targeted drugs, are more effective in the treatment of psoriasis and dermatitis than traditional approaches, with minimum side effects. The results of new drug research have opened new possibilities for the treatment of psoriasis and dermatitis, guided the path of future scientific research, and significantly improved the quality of life of patients.