To improve the quality of talent cultivation in vocational colleges and strengthen students’ comprehensive quality and professional abilities, this paper explores the mode innovation of football teaching in vocational colleges based on the perspective of “integration of sports and education.” The study aims to construct a dual-driven talent cultivation model of “professional orientation + football literacy”, forming a “skilled + sports-type” composite talent training system. Additionally, the study proposes an innovative mode of “integration of in-class and extracurricular activities + school-enterprise collaboration” to promote the reform of football teaching mode in vocational colleges. The research presents multiple measures, including resource optimization, teacher empowerment, and deepening collaboration, to facilitate the transformation and innovation of football teaching mode in vocational colleges under the current background of “integration of sports and education.”