Objective: To explore effective methods for clinical teaching of palliative treatment for gastrointestinal tumors and enhance medical students’ clinical application abilities and professional qualities in this field. Methods: Ninety-two students undergoing standardized residency training in clinical medicine during the 2023–2024 academic year at a certain institution were selected as the study subjects. A three-dimensional teaching model combining “theoretical lectures + clinical case discussions + bedside practical guidance” was employed to conduct teaching practice on palliative treatment for gastrointestinal tumors. Teaching effectiveness was evaluated through theoretical assessments, clinical skill operation scores, and teaching satisfaction questionnaires. Results: The average score of the theoretical assessment for the 92 students was 82.36 ± 5.18 points, and the average score for clinical skill operations was 84.52 ± 4.87 points. Eighty-nine students expressed satisfaction with the teaching model, resulting in a satisfaction rate of 96.74%. Conclusion: The three-dimensional teaching model can effectively improve the quality of clinical teaching on palliative treatment for gastrointestinal tumors, helping students quickly master core knowledge and skills, meeting the demands of clinical teaching, and is worthy of promotion and application.