Objective: To analyze the effect of rehabilitation nursing intervention on the quality of life of neurological patients with sequelae of cerebral hemorrhage. Methods: 70 patients with cerebral hemorrhage and sequelae who were admitted to the hospital from February 2022 to February 2024 were randomly divided into the observation group and the control group, and were subjected to conventional nursing measures and rehabilitation nursing intervention modes respectively to analyze the effects of the interventions in the two groups. Results: After the intervention, the observation group had lower nerve damage, stronger independent self-care ability, and better recovery of limb function, P < 0.05. After the intervention, the observation group had higher quality of life scores, and lower probability of complications, P < 0.05. Conclusion: the neurology department involves relatively more patients with cardiovascular and cerebrovascular diseases, and the presence of cerebral hemorrhage in the patients may lead to several sequelae, which will affect the daily lives of the patients. The implementation of rehabilitation nursing interventions can improve the recovery rate of patients’ neurological function and limb function, improve patients’ self-care ability, and maintain patients’ quality of life.