Objective: To analyze the effect of using a comprehensive nursing intervention model for patients with diabetes mellitus and urinary tract infections. Methods: 60 patients with diabetes mellitus combined with urinary tract infection who were admitted to the hospital from November 2021 to November 2023 were randomly divided into the observation group and the control group, and were treated with conventional nursing interventions and comprehensive nursing interventions respectively. The nursing status of the two groups was compared and analyzed. Results: After the intervention, the observation group showed lower levels of fasting blood glucose and other indicators, and lower anxiety and depression scores, P < 0.05. After the intervention, the observation group’s blood creatinine and other biochemical indicators improved significantly, P < 0.05. Conclusion: For the treatment of patients with both diabetes mellitus and urinary tract infections, nursing staff should pay attention to the development of nursing interventions to enhance the level of patients’ glucose control, improve the patients’ bad moods, and improve patients’ therapeutic efficacy.