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Volume 4,Issue 2

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31 December 2025
Epigenetic Regulatory Mechanisms of ZNF304 in Colorectal Cancer and Its Role in Migration and Invasion
Ting Zheng
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1 College of Health Management, Shanghai Jian Qiao University, Shanghai 201306, China,
IJGPN 2025 , 3(0), 265–270; https://doi.org/10.26689/ijgpn.v3iSpecial.13954
© 2025 by the Authors. Licensee Whioce Publishing, Singapore. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution -Noncommercial 4.0 International License (CC BY-NC 4.0) ( https://creativecommons.org/licenses/by-nc/4.0/ )
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Abstract

Colorectal cancer is one of the leading causes of cancer-related deaths worldwide, and its development involves complex genetic and epigenetic mechanisms. Epigenetic regulation, especially DNA methylation, plays a crucial role in tumorigenesis, progression, and metastasis. Epithelial-mesenchymal transition (EMT) is an important process promoting tumor cell invasion and metastasis, and epigenetic regulators such as TRIM28 and ZNF304 play key roles in this process. TRIM28 can regulate the expression of EMT-related genes by activating the TGF-β signaling pathway and histone modification; ZNF304, as a member of the C2H2 zinc finger transcription factor family, is closely related to cell survival, migration, and metastasis in various tumors. This review summarizes the epigenetic regulatory mechanisms of TRIM28 and ZNF304 in colorectal cancer, exploring their roles in the EMT process and tumor migration and invasion, providing new insights for the study of colorectal cancer metastasis mechanisms and targeted therapy.

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