With the upgrading of healthcare industry demands and the deepening of industry-education integration policies in China, the technological innovation and service model integration of intelligent oxygen therapy equipment have become a key path to address industry bottlenecks. This study focuses on the “oxygen-enriched + negative oxygen ion” composite device (abbreviated as “dual-oxygen equipment”), exploring its innovative design and healthcare applications under industry-education integration. Research shows that this equipment, through a triple physical purification system combining “activated carbon adsorption + negative oxygen ion deposition + active silver ion sterilization” with nebulization rehabilitation functions, effectively enhances non-pharmacological intervention outcomes for chronic respiratory diseases. With 93% oxygen-enriched output capacity and PM2.5 purification efficiency ≤35 μg/m³, it provides reliable technical support for community and home-based healthcare scenarios. Additionally, the collaborative “R&D-talent-service” closed-loop mechanism between schools and enterprises—through joint laboratory construction, development of occupational standards, and service package design—has achieved full-chain breakthroughs from technical prototypes to industrial applications of intelligent oxygen therapy equipment, offering replicable practical paradigms for high-quality development in the healthcare industry.