Coronary heart disease (CHD) is one of the chronic cardiovascular diseases with a high disability rate, high morbidity, and high mortality worldwide. Long-term drug management is of great significance to control the disease, reduce the recurrence rate of cardiovascular events, and improve the quality of life of patients. However, the drug compliance of patients with CHD is generally not high, and the current situation is worrying. Studies have shown that there are differences in drug compliance among patients in different regions and different age groups. This study reviewed the concept of coronary heart disease, the concept and connotation of medication compliance, the analysis of medication compliance status of patients with coronary heart disease and the analysis of influencing factors, providing basis for clinical medical staff to quickly screen out high-risk patients with low compliance, and to carry out early and accurate intervention, in order to effectively improve patient medication compliance, improve long-term prognosis, reduce readmission rate and medical burden.