Background: Acute myocardial infarction (AMI) demands timely and effective intervention to prevent severe complications and improve patient outcomes. However, differences in emergency nursing protocols can affect the success of treatment. Therefore, evaluating the effectiveness of an optimized comprehensive emergency nursing model, which includes advanced assessment methods and individualized care strategies, is crucial for enhancing treatment protocols. Objective:  This study aimed to assess the impact of a comprehensive emergency nursing model on patients diagnosed with acute myocardial infarction (AMI) within the cardiology department, focusing on optimizing rescue efficiency and patient outcomes. Methods: This retrospective study analyzed data from 90 AMI patients admitted to the hospital between January and December 2024. The study was conducted within the cardiology department of our hospital. The patients were divided into two groups: an intervention group (n=45) and a control group (n=45). The intervention group received care under the comprehensive, optimized emergency nursing model, while the control group received standard emergency care. Evaluation parameters included rescue time, clinical outcomes, and patient satisfaction with nursing care. Results: No significant differences in baseline characteristics were found between the two groups. However, the intervention group (n=45) demonstrated significantly shorter rescue times compared to the control group (n=45) in all measured parameters, including triage assessment time (7.49 ± 1.29 vs. 12.49 ± 2.18 minutes) and total emergency time (28.37 ± 3.14 vs. 48.64 ± 5.65 minutes), with P-values < 0.001. Additionally, the intervention group showed significantly lower rates of clinical complications, including heart failure (4.44% vs. 17.78%) and recurrent myocardial infarction (2.22% vs. 17.78%), and higher patient satisfaction across all parameters, with P-values < 0.001. These findings demonstrate the effectiveness of the comprehensive emergency nursing model in enhancing AMI care. Conclusion: The comprehensive emergency nursing model significantly improved rescue efficiency, reduced complications, and increased patient satisfaction in AMI care, demonstrating its clinical effectiveness.