As a critical department for hospital infection control, the disinfection supply center is responsible for cleaning, disinfecting, sterilizing, and distributing reusable medical devices and items across the hospital. Geriatric departments, due to their patient population’s weakened immune systems and multiple underlying conditions, are particularly vulnerable to infection outbreaks. The material transfer process between these two departments directly impacts infection prevention effectiveness. This study analyzes existing issues in current material transfer procedures between disinfection centers and geriatric departments, proposes targeted optimization measures, and explores how process improvements enhance standardized material management, reduce contamination risks, and strengthen staff infection control awareness. The findings aim to provide practical references for hospitals to refine infection control systems and ensure elderly patient safety, ultimately advancing comprehensive infection management capabilities.