Objective: To explore the practical effect of Failure Mode and Effects Analysis (FMEA) combined with traditional Chinese medicine (TCM) characteristic nursing in preventing pressure injuries in patients with kidney disease, providing a referenceable practical basis for clinical nursing work. Methods: From January 2023 to June 2024, 120 patients with kidney disease in the nephrology department of the hospital were selected and randomly divided into a control group and an intervention group, with 60 cases in each group. The control group received routine pressure ulcer prevention nursing, while the intervention group received additional FMEA management mode and TCM characteristic nursing. The incidence of pressure ulcers, injury staging, nutritional status, skin scores, and nursing satisfaction were compared between the two groups. Results: The incidence of pressure injuries in the control group was 20.00%, while that in the intervention group was only 5.00%. Moreover, the injuries in the intervention group were milder and occurred later on average, with statistically significant differences between the two groups (P<0.05). In terms of nursing satisfaction, the intervention group reached 96.67%, significantly higher than the 83.33% in the control group, with this difference also passing statistical testing (P<0.05). Conclusion: The combined application of FMEA and TCM characteristic nursing can effectively reduce the risk of pressure injuries in patients with kidney disease, improve their nutritional and skin status, and enhance nursing satisfaction, demonstrating high clinical promotion value.