Highway is an important type of road in China’s road network, and it also carries a larger portion of transportation task. Safety is the first indicator in the stage of its use, so it is necessary to carry out safety design focusing on the highway interchange exit ramp to effectively prevent traffic accidents. Therefore, in this paper, the important significance of the safety design of the highway interchange exit ramp and the key factors affecting its safety were discussed and studied in detail, and finally corresponding strategies were proposed for discussion and communication.