The convergence of artificial intelligence (AI) and the metaverse has precipitated a paradigm shift from tool-centric interaction to “intelligent agents and real-time synthesis.” Traditional tool-oriented curricula prove inadequate for cultivating cross-contextual integrative competence. Building on the authors’ prior conference paper, this research presents a four-tier “philosophy-method-technology-practice” curriculum that operationalizes technological, cognitive, creative, and critical thinking into the measurable “4-Mind” framework, enacted within a blended-learning environment. Questionnaire-based assessment reveals significant gains in learners’ 4-Mind literacy, furnishing the first validated and replicable template for far-transfer cultivation in AI-era interaction education.