Based on the current situation and dilemma of traditional clinical teaching in neurology, content design and case screening are carried out for the “microteaching + case database” integration model by establishing the development principles of microteaching resources and the construction standards of the case database. Then, we analyze from four stages: pre-class (microclass guidance + case pre-analysis), classroom teaching (microclass intensive lecture + case discussion), after-class practice (case simulation + microclass consolidation), and teaching evaluation (diversified assessment + feedback improvement). The application path of the “microclass + case bank” integration model in clinical teaching of neurology is helpful to cultivate the clinical competence of medical students in neurology and has important promotional value.