This paper combs the rise and development process of Qi business and Qi business culture, and concludes that Qi business culture has such spiritual connotations as pragmatism, openness, integrity, innovation, self-improvement and flexibility. It is not only a part of Chinese excellent traditional culture, but also has important time value for today’s commercial and trade activities and the cultivation of financial professionals, it can be used to guide the training of finance and economics professionals in higher vocational institute, establish the curriculum system of professional innovation integration, cultural penetration, progressive level and the hybrid teaching mode of matrix theory and practice integration, so as to cultivate outstanding technical and skilled talents of finance and economics major.