In response to current issues in basic nursing course instruction, this article proposes a teaching model reform based on the OBE (outcome-based education) concept. By resetting course objectives, innovating teaching methods and content, reforming the assessment and evaluation system, as well as conducting practical explorations and case studies, the aim is to enhance teaching quality and cultivate students’ practical abilities and comprehensive qualities. The article elaborates on the application of the OBE concept in nursing education and its effectiveness evaluation, providing a valuable reference for nursing education reform.