Combining the characteristics of the course “Comprehensive Training of E-Commerce Live Streaming,” this paper embeds the CDIO (Conceive-Design-Implement-Operate) method into the live streaming training process, carries out the virtual scene “e-commerce live streaming” course design and project-based teaching reform that integrates teaching training with learning effects, and establishes a set of cross-professional student live streaming training procedures guided by the CDIO engineering method. The training results show that the CDIO practical teaching model supported by data feedback plays an important role and significance in improving students’ learning effects, and also provides some new experiences for integrating engineering thinking into the construction of new liberal arts.