With increasingly frequent international exchange and cooperation in universities, cross-cultural communication has become an important dimension of English translation teaching in universities. Universities should actively optimize their educational models, deepen international exchange and cooperation, build bridges for cultural exchanges, and create a new international educational environment. Starting from the background of international exchange and cooperation, this article deeply explores the inherent needs of English translation teaching in universities, discusses the practice of cross-cultural translation teaching, enhances students’ cultural awareness and cross-cultural translation abilities, and provides a reference for the reform and innovation of English translation in universities.