In recent years, with the continuous development of educational digitalization, the integration model of SPOC (Small Private Online Course) and flipped classroom can integrate online teaching resources and offline teaching resources, overcome the shortcomings of traditional teaching models, and enhance students' enthusiasm for learning and autonomous learning ability. This model has become a popular direction in the reform of teaching models. Meanwhile, the advantages of the Zhihuishu knowledge graph platform, such as knowledge coherence and complete teaching modules, are highly beneficial for the promotion of the flipped classroom teaching model based on SPOC. This research will adopt methods such as literature review, investigation and research, questionnaire survey, and in-depth interview to analyze the application effect and optimization path of the flipped classroom teaching model based on SPOC on the Zhihuishu platform in college English teaching. The theoretical basis, practical effect and existing problems of the model were specifically analyzed, and corresponding optimization suggestions were put forward.