To investigate the effect of thrombectomy combined with in travascular injection (PTA) on the treatment of iliac vein compression syndrome (IVCS) and deep vein thrombosis (DVT). 50 patients with IVCS and DVT were enrolled in this study from January 2013 to December 2016. They were randomly divided into two groups. The control group was treated with thrombolytic therapy. The study group was treated with thrombus aspiration combined with PTA. The therapeutic effect of the study group was significantly better than that of the control group (P < 0.05).Thrombectomy combined with intravascular stenting for the treatment of iliac vein compression syndrome and deep vein thrombosis is better than the second stage.