Objective: To analyze the application effectiveness of the integrated medical-nursing comprehensive care model in cases of cerebral infarction and clarify its clinical practical value for the patient rehabilitation process. Methods: A total of 60 patients with cerebral infarction admitted from June 2024 to December 2024 were selected as the research subjects and randomly divided into a control group and a research group, with 30 cases in each group. Patients in the control group received routine clinical nursing measures, while those in the study group underwent collaborative healthcare intervention in addition to routine nursing. The intervention included joint disease assessment, personalized rehabilitation training guidance, psychological counseling, and continuous nursing services after discharge. A comparative study was conducted by evaluating indicators such as the scores on adverse emotion scales, the extent of neurological recovery, the effectiveness rate of clinical rehabilitation treatment, and the level of satisfaction with nursing services between the two groups. Results: After the intervention, the scores on the Self-Rating Anxiety Scale (SAS) and the Self-Rating Depression Scale (SDS) in the study group decreased to (40.12 ± 5.01) and (41.36 ± 5.20), respectively, both significantly lower than those in the control group, which were (47.36±5.82) and (48.95 ± 5.63), respectively. The differences between the two groups were statistically significant (p < 0.05). The improvement in the neurological deficit scores of patients in the study group reached (9.18 ± 2.04), higher than that in the control group, which was (5.17 ± 1.82) (p < 0.05). The overall clinical rehabilitation effectiveness rate in the study group was 93.3%, significantly higher than that in the control group, which was 73.3%. The satisfaction rate with nursing services in the study group reached 96.7%, also higher than that in the control group, which was 83.3%. The differences between the two groups were statistically significant (p < 0.05). Conclusion: The integrated healthcare nursing model can effectively alleviate adverse emotional states in patients with cerebral infarction, facilitate the repair and reconstruction of neurological function, improve the effectiveness of clinical rehabilitation treatment and satisfaction with nursing services, and thus holds high value for clinical promotion and application.