ARTICLE
Volume 10,Issue 7
10 March 2026
Research Progress of Insulin-like Growth Factor-1 in the Diagnosis and Efficacy Prediction of Sarcopenia in the Elderly
Yang Liao ,
Shujin Guo
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1
Department of Geriatrics, School of Medicine and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan, China,
2
Department of Health Management Center, Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, Sichuan, China,
JCNR 2026 , 10(2), 69–74;
https://doi.org/10.26689/jcnr.v10i2.14092
© 2026 by the Authors. Licensee Whioce Publishing, Singapore. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
Abstract
Sarcopenia in the elderly is a syndrome characterized by age-related progressive loss of muscle mass, decline in muscle strength, and deterioration of muscle function. Its high incidence significantly increases the risk of falls, fractures, disability, and mortality among the elderly, posing a global public health challenge for geriatric health. Insulin-like growth factor-1 (IGF-1), a key cytokine regulating muscle growth, repair, and metabolism, exhibits a progressive decline in serum levels with aging and is closely associated with the onset and progression of sarcopenia in the elderly. This study reviews the research progress of IGF-1 in the diagnosis and efficacy prediction of sarcopenia in the elderly, providing theoretical references for precise diagnosis, treatment, and prognosis assessment of sarcopenia in the elderly.
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