Myasthenia gravis (MG) is a chronic autoimmune disease characterized by impaired transmission at the neuromuscular junction. Conventional clinical treatments show unsatisfactory efficacy and severe adverse reactions, while traditional Chinese medicine (TCM) presents unique advantages in its management. From the perspective of integrated traditional Chinese and Western medicine, this paper investigates the effects of Qishen Dihuang Granules on patients with MG based on modern understandings of the pathogenesis of MG and TCM theories. The pharmacological mechanisms and theoretical basis of the granules are elaborated from four aspects: regulating immune function, protecting the structure and function of the neuromuscular junction, improving TCM syndromes and clinical symptoms, and enhancing efficacy while reducing toxicity. The results show that Qishen Dihuang Granules can effectively correct immune imbalance, alleviate damage to the neuromuscular junction, improve clinical symptoms and TCM syndromes, assist in enhancing therapeutic effects and reducing drug toxicity. It demonstrates favorable clinical application value and provides an important theoretical basis for the integrated treatment of MG with traditional Chinese and Western medicine.