Correlation between Dynamic Changes of Serum Tumor Markers and Recurrence Risk in Patients after Thyroid and Breast Surgery

© 2026 by the Authors. Licensee Whioce Publishing, Singapore. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )

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Abstract

Objective: To explore the correlation between the dynamic changes of serum tumor markers and the risk of recurrence in postoperative patients undergoing breast surgery. Method: Sixty postoperative patients of breast surgery from January 2024 to December 2025 were selected and divided into an experimental group (malignant, 30 cases) and a control group (benign, 30 cases). Detect serum CEA and CA15-3/Tg levels at multiple time points before and after surgery, and record recurrence events during a 12-month follow-up. Result: The CEA and CA15-3/Tg levels in the experimental group were significantly lower than those before surgery at 1, 3, 6, and 12 months postoperatively (p < 0.05). The increase of CEA (HR = 2.84, p = 0.008) and CA15-3/Tg (HR = 3.12, p = 0.004) in the third month after surgery was significantly correlated with recurrence, and the combined prediction AUC was 0.913. Conclusion: The dynamic changes of serum CEA and CA15-3/Tg in the third month after surgery can effectively predict the risk of postoperative recurrence in breast surgery, and the combined detection value is higher.

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