Analysis of the Efficacy of Multi-Target Receptor Modulators Combined with Modified Electroconvulsive Therapy in BD Patients with Comorbid Multisystem Somatic Diseases

Yuyu Shang, Sijin Li

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¹ Inner Mongolia Brain Hospital (Third Hospital), Hohhot 010010, Inner Mongolia Autonomous Region, China,

JCNR 2026 , 10(5), 1–8; https://doi.org/10.26689/jcnr.v10i5.14762

© 2026 by the Authors. Licensee Whioce Publishing, Singapore. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )

Abstract

Objective: To evaluate the efficacy of multi-target receptor modulators combined with modified electroconvulsive therapy in BD patients with comorbid multisystem somatic diseases. Methods: A total of 68 BD patients with comorbid multisystem somatic diseases treated from May 2022 to May 2025 were selected as samples and randomly divided into groups by drawing lots. Group A received modified electroconvulsive therapy (MECT) combined with the multi-target receptor modulator quetiapine, while Group B received quetiapine alone. Results: Group A showed superior efficacy, Mini-Mental State Examination (MMSE) scores, Hamilton Depression Rating Scale (HAMD) scores, Bech-Rafaelsen Mania Rating Scale (BRMS) scores, and serum factor indicators compared to Group B, with p < 0.05; there was no significant difference in the adverse reaction rate between Group A and Group B, with p > 0.05. Conclusion: The combination of multi-target receptor modulators and modified electroconvulsive therapy can improve intellectual status, alleviate manic and depressive symptoms, and is highly effective and feasible in the treatment of BD patients with comorbid multisystem somatic diseases.

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