ARTICLE
Volume 10,Issue 7
30 June 2026
Flow Rate Control and Optimization of RCA Infusion System Based on ADRC and Two-Stage Calcium Supplementation Model
Chao Xu ,
Damin Ding ,
Chaobin Wang
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1
Shanghai Institute of Medical Device Testing, Shanghai 201318, China,
2
Shanghai University of Engineering Science, Shanghai 201620, China; Shanghai Superb Medical Technology Co., Ltd., Shanghai 201612, China,
3
Shanghai University of Engineering Science, Shanghai 201620, China,
JCNR 2026 , 10(6), 292–298;
https://doi.org/10.26689/jcnr.v10i6.15534
© 2026 by the Authors. Licensee Whioce Publishing, Singapore. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
Abstract
Based on the established two-stage mathematical model of Regional Citrate Anticoagulation (RCA), an automated RCA infusion system is constructed. Aiming at the flow rate accuracy problem of peristaltic pumps under variable pressure environments, a flow rate control algorithm based on Active Disturbance Rejection Control (ADRC) is designed, combined with pressure compensation and surface calibration methods. The experimental results show that this method can achieve high-precision infusion under different pressure differences and meet clinical requirements.
References
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Zheng Y, Xu Z, Zhu Q, et al., 2013, Citrate Pharmacokinetics in Critically Ill Patients with Acute Kidney Injury. PLoS One, 8(6): e65992.
Han J, 1998, Active Disturbance Rejection Control and Its Application. Control and Decision, 13(1): 19–23.
Han J, Zhang W, 1999, Active Disturbance Rejection Control for Large Time-Delay Systems. Control and Decision, 14(4): 354–358.
Gong D, Ji D, Xie H, et al., 2001, The Effects of Dialysate and Ultrafiltration Flow Rate on Solute Clearance During Continuous Renal Replacement Therapy. Zhonghua Nei Ke Za Zhi, 40: 183–186.
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