Abstract: This article reported a case of acne associated blepharokeratoconjunctivitis (BKC) in a young woman. During her pregnancy, to reduce the systemic use of drugs due to its side effect, localized eye drop, oral administration of Chinese medicine and fumigation treatment were adopted. In integrated Chinese and Western medicine treatments, localized treatment simultaneously with the intrinsic conditioning of the patient’s physique could treat both the symptoms and root causes of disease. It can effectively improve clinical efficacy, shorten the course of the disease and reduce patient suffering and recurrence.