Objectives: To investigate the effect of traditional Mongolian osteopathy manual reduction with medicinal wine spraying massage and small splint external fixation therapy for treatment of Neerll-type distal humerus fractures. Methods: Sample selection was carried out during time period from November 2014 to May 2019. Sixty-six patients admitted to our hospital were selected as sample patients. The control group was given plaster treatment, while the observation group was given traditional Mongolian osteopathy manual reduction with medicinal wine spraying massage and small splint external fixation therapy. Efficacy for the two groups of patients was observed. Results: In this study, the total effective rate of observation group patients with treatment of traditional Mongolian osteopathy manual reduction with medicinal wine spraying massage and small splint external fixation therapy was 100%. Meanwhile, total effective rate of patients in control group was 87.88%. The difference was significant, p<0.05. Conclusions: In this study of clinical treatment, traditional Mongolian osteopathy manual reduction with medicinal wine spraying massage and small splint external fixation therapy could provide better therapeutic effect for treatment of patients with Neerll-type distal humerus fracture. At the same time, it reduces economic burden of patients. It has higher promotion value for clinical practice.