Objective: To investigate the effect and value of perioperative nursing intervention on postoperative recurrent grade II-I left frontal astrocytoma. Method: Nursing care procedures: left frontal lobe of the patient was occupied by a large space. Clinical teaching of nursing was strengthened. Preoperative, intraoperative and postoperative care and ward patrol were enhanced. Close attention was paid on consciousness, pupil, vital signs, body temperature, lungs condition, cranial and nerve function of the patient. Extra care was taken in keeping the incision clean and dry. Blood diffusion condition in wound was observed. Active cooperation with doctor was taken to prevent occurrence of pulmonary infection, urinary tract infection, pressure ulcer and other complication. Results: After operation, the patient had stable condition, clear mind and consciousness. There was no occurrence of epilepsy but intracranial hemorrhage. Pneumatosis was relieved. There was no infection and other complication. Conclusion: Application of comprehensive nursing intervention could effectively improve quality of life of patient and reduce incidence of postoperative complication in patients with brain tumor.