Objective: To evaluate the efficacy of transbronchoscopic large volume lung lavage in the treatment of pneumoconiosis complicated with chronic obstructive pulmonary disease (COPD). Methods: The clinical data of 80 patients with pneumoconiosis complicated with COPD admitted to our hospital from June 2017 to January 2019 were retrospectively analyzed. 40 patients in the control group were treated with conventional drugs and 40 patients in the observation group treated with conventional drugs plus transbronchoscopic large-volume lung lavage. Dyspnea score and healthy quality of life were compared between the two groups. Results: the scores of dyspnea in the observation group were significantly lower than those in the control group at 12, 24 and 48 weeks after treatment, and the (SGRQ) scores of George's respiratory problems questionnaire in the observation group were significantly lower than those in the control group at 12, 24 and 48 weeks after treatment. Conclusion: Thetransbronchoscopic large volume of lung lavage has a significant effect on the treatment of pneumoconiosis patients with COPD, which can effectively reduce the degree of dyspnea and improve the quality of life.