Objective: To evaluate the effect of the sandwich teaching model on the learning effect of nursing students. Methods: The Chinese and English databases of CNKI, WanFang, Vip, superstar, and PubMed were searched by computer, and the data were analyzed by Rev Man 5.3 software after literature quality evaluation. Results: Meta-analysis showed that the theoretical and operational performance of the nursing students in the sandwich teaching method was better than that of the traditional teaching group. Conclusion: The sandwich approach was superior to the traditional teaching method in the learning outcomes of nursing students.