Objective: To observe the effect of glycerol fructose combined with mannitol in the treatment of patients with clinical intracerebral hemorrhage complicated by cerebral edema and increased intracranial pressure, and to evaluate the clinical application value of this treatment. Methods: Seventy patients with cerebral hemorrhage complicated by brain edema were randomly divided into observation and control groups. Both groups had exactly the same number of study participants. There were some differences in specific treatment methods. The specific process is as follows: The control group was treated with mannitol, while the observation group was treated with dual-purpose glycerol fructose. Several important indicators after treatment in the two groups were scored, the effects between different groups were compared, and the effect of clinical treatment was evaluated. Results: The final effect was compared and analyzed. After data analysis, we found that the intracranial pressure of the observation group was lower, the volume of brain edema was significantly reduced (P < 0.05), and the NIH Stroke Scale/Score (NIHSS) was lower (P < 0.05). Conclusion: Using mannitol combined with glycerol fructose can achieve better treatment effect by significantly improving the problem of brain edema.