The objective of this paper is to outline Chief Physician Defen Wang’s clinical experience in perimenopausal sweating syndrome differentiation and treatment, to inherit Mr. Gao’s academic concept of mediation technique, and to integrate multiple prescriptions under Mr. Gao’s thinking. The deficiency is based on the deficiency of liver and kidney Yin, the weakness of spleen and stomach, and the standard is the imbalance of Ying and Wei, the imbalance of Qi, blood and body fluid, and the main method of treatment is nourishing liver and kidney, soothing liver and invigorating spleen, regulating Ying and Wei, as well as tonifying Qi and absorbing fluid.