Objective: To explore and analyze the effect of high-quality nursing on patients with epidemic hemorrhagic fever with renal syndrome. Methods: Ninety patients with epidemic hemorrhagic fever with renal syndrome treated in Huyi District People’s Hospital from October 2021 to January 2022 were randomly divided into an experimental group and a control group, with 45 cases in each group. The control group received routine nursing and the experimental group received high-quality nursing. The effect of routine nursing and high-quality nursing were compared and analyzed based on the Self-Rating Anxiety Scale (SAS), Self-Rating Depression Scale (SDS), the degree of satisfaction with nursing care, and the patients’ quality of life. Results: Before nursing, there was no significant difference in the patients’ psychological state between the two groups (P > 0.05); after nursing, there was significant difference in the patients’ psychological state between the two groups (P < 0.05); the degree of satisfaction with nursing care of the experimental group was significantly higher than that of the control group (P < 0.05); comparing the quality of life of the two groups, the quality-of-life score of the control group was significantly lower than that of the experimental group (P < 0.05). Conclusion: For patients with epidemic hemorrhagic fever with renal syndrome, high-quality nursing can significantly and effectively improve their psychological state, level of satisfaction with nursing care, and quality of life.