Objective: This paper aims to investigate the value of individualized care for critically ill patients receiving
continuous blood purification therapy. Methods: 89 cases of critically ill patients who were treated from June 2021 to June 2023 were randomly divided into groups, with individualized care in group A and routine care in group B. The differences in clinical indicators, purification effect, quality of life, and complications of blood purification were compared between the groups. Results: Heart rate, respiration, body temperature, and other indicators in group A were better than those in group B, P < 0.05. C-reactive protein (CRP), β2-microglobulin (β2-MG), blood urea nitrogen (BUN), and phosphorus (P) in group A were lower than those in group B, P < 0.05. Group A had higher quality of life than Group B, P < 0.05. The complication rate of blood purification in Group A was lower than that in Group B, P < 0.05. Conclusion: During continuous blood purification in critically ill patients, individualized nursing intervention can enhance the effect of blood purification, improve the physiological indicators of patients, and reduce the complications of blood purification, which is highly effective and feasible.